fadd Fas (tnfrsf6)-associated via death domain [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: faddprovided by ZNC
Official Full Name: Fas (tnfrsf6)-associated via death domainprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070606-3
See related: Ensembl:ENSDARG00000103021 AllianceGenome:ZFIN:ZDB-GENE-070606-3
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable caspase binding activity and death receptor binding activity. Acts upstream of or within positive regulation of apoptotic process. Predicted to be part of CD95 death-inducing signaling complex. Is expressed in several structures, including axis; brain; germ ring; immature eye; and ventral mandibular arch. Human ortholog(s) of this gene implicated in leukemia and primary immunodeficiency disease. Orthologous to human FADD (Fas associated via death domain). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (54312857..54319452, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (54043180..54049850, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

establish that pax2 in combination with vax2 directly regulate the fas-associated death domain (fadd) gene
Title: Pax2 regulates a fadd-dependent molecular switch that drives tissue fusion during eye development.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables caspase binding	IBA Inferred from Biological aspect of Ancestor more info
enables death receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in extrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of innate immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of CD95 death-inducing signaling complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: FAS-associated death domain protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001386360.1 → NP_001373289.1 FAS-associated death domain protein

Status: VALIDATED

Source sequence(s)

CU928764

UniProtKB/TrEMBL

A0A0R4IXF0, A0A8M1QLU8

Related

ENSDARP00000140007.1, ENSDART00000172396.2

Conserved Domains (2) summary

cd08306
Location:105 → 189

Death_FADD; Fas-associated Death Domain protein-protein interaction domain

cd08336
Location:6 → 86

DED_FADD; Death Effector Domain found in Fas-Associated via Death Domain