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    enc3 ectodermal-neural cortex 3 [ Danio rerio (zebrafish) ]

    Gene ID: 327531, updated on 9-Dec-2024

    Summary

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    Official Symbol
    enc3provided by ZNC
    Official Full Name
    ectodermal-neural cortex 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5742
    See related
    Ensembl:ENSDARG00000058322 AllianceGenome:ZFIN:ZDB-GENE-030131-5742
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    enc1; enc1l; id:ibd3303; wu:fi15g12
    Summary
    Acts upstream of or within determination of heart left/right asymmetry and determination of liver left/right asymmetry. Is expressed in several structures, including anterior neural rod; germ ring; mesoderm; nervous system; and tail bud. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See enc3 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (10781957..10795946)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (10752275..10766264)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene transmembrane serine protease 9 Neighboring gene LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene translocase of inner mitochondrial membrane 13 homolog (yeast) Neighboring gene rho/rac guanine nucleotide exchange factor (GEF) 18b Neighboring gene insulin receptor b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. ENC1-like integrates the retinoic acid/FGF signaling pathways to modulate ciliogenesis of Kupffer's Vesicle during zebrafish embryonic development. Qian M, et al. Dev Biol, 2013 Feb 1. PMID 23201577
    2. Saltatory evolution of the ectodermal neural cortex gene family at the vertebrate origin. Feiner N, et al. Genome Biol Evol, 2013. PMID 23843192, Free PMC Article
    3. A gene expression screen in zebrafish embryogenesis. Kudoh T, et al. Genome Res, 2001 Dec. PMID 11731487
    4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ENC1-like integrates the retinoic acid/FGF signaling pathways to modulate ciliogenesis of Kupffer's Vesicle during zebrafish embryonic development
      Title: ENC1-like integrates the retinoic acid/FGF signaling pathways to modulate ciliogenesis of Kupffer's Vesicle during zebrafish embryonic development.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within determination of heart left/right asymmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within determination of liver left/right asymmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ectodermal-neural cortex 3
    Names
    ectodermal-neural cortex (with BTB-like domain)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001402.2 → NP_001001402.2  ectodermal-neural cortex 3

      See identical proteins and their annotated locations for NP_001001402.2

      Status: VALIDATED

      Source sequence(s)
      BX908398
      UniProtKB/TrEMBL
      F6P777, Q789P9, Q7ZT06
      Related
      ENSDARP00000075626.3, ENSDART00000081183.4
      Conserved Domains (6) summary
      smart00612
      Location:539 → 585
      Kelch; Kelch domain
      PHA03098
      Location:60 → 566
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:330 → 374
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:36 → 140
      BTB; BTB/POZ domain
      pfam01344
      Location:329 → 374
      Kelch_1; Kelch motif
      pfam07707
      Location:149 → 251
      BACK; BTB And C-terminal Kelch

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      10781957..10795946
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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