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    zgc:136929 zgc:136929 [ Danio rerio (zebrafish) ]

    Gene ID: 678649, updated on 9-Dec-2024

    Summary

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    Official Symbol
    zgc:136929provided by ZNC
    Official Full Name
    zgc:136929provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060421-4235
    See related
    Ensembl:ENSDARG00000019213 AllianceGenome:ZFIN:ZDB-GENE-060421-4235
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fa96d06; wu:fa96d06
    Summary
    Predicted to enable DNA-binding transcription factor binding activity; transcription coregulator activity; and transcription coregulator binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human CTBP1 (C-terminal binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See zgc:136929 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (21145808..21199502)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (20848544..20902254)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene si:dkey-74k8.4 Neighboring gene aldolase b, fructose-bisphosphate Neighboring gene macrophage erythroblast attacher, E3 ubiquitin ligase Neighboring gene protein phosphatase 2, regulatory subunit B, gamma b Neighboring gene si:ch211-175m2.4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC136929

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    C-terminal-binding protein 1
    NP_001035480.1
    XP_005173191.1
    XP_068069342.1
    XP_068069343.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040390.1 → NP_001035480.1  C-terminal-binding protein 1

      See identical proteins and their annotated locations for NP_001035480.1

      Status: PROVISIONAL

      Source sequence(s)
      BC115334
      UniProtKB/TrEMBL
      A0A8M1N975, Q1RLQ4
      Related
      ENSDARP00000145521.1, ENSDART00000192678.1
      Conserved Domains (2) summary
      COG0111
      Location:55 → 354
      SerA; Phosphoglycerate dehydrogenase or related dehydrogenase [Coenzyme transport and metabolism, General function prediction only]
      cd05299
      Location:28 → 346
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      21145808..21199502
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068213241.1 → XP_068069342.1  C-terminal-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M1N975, Q1RLQ4
      Related
      ENSDARP00000059795.6, ENSDART00000059796.8

    2. XM_068213242.1 → XP_068069343.1  C-terminal-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M1N975, Q1RLQ4
      Related
      ENSDARP00000130473.1, ENSDART00000168539.2

    3. XM_005173134.5 → XP_005173191.1  C-terminal-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A2R8QPP7, A0A8M2BKF4
      Related
      ENSDARP00000155016.1, ENSDART00000187440.1
      Conserved Domains (2) summary
      COG0111
      Location:44 → 343
      SerA; Phosphoglycerate dehydrogenase or related dehydrogenase [Coenzyme transport and metabolism, General function prediction only]
      cd05299
      Location:17 → 335
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394903.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      2431..42137
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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