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    and1 actinodin1 [ Danio rerio (zebrafish) ]

    Gene ID: 794315, updated on 9-Dec-2024

    Summary

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    Official Symbol
    and1provided by ZNC
    Official Full Name
    actinodin1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9105
    See related
    Ensembl:ENSDARG00000088514 AllianceGenome:ZFIN:ZDB-GENE-030131-9105
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fa96a05; fa99d09; wu:fa96a05; wu:fa99d09
    Summary
    Acts upstream of or within cartilage development and fin development. Is expressed in brain; median fin fold; pectoral fin; and pectoral fin bud. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See and1 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (26279503..26283359, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (26134462..26138318, complement)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137489249 Neighboring gene adiponectin, C1Q and collagen domain containing, a Neighboring gene COP9 signalosome subunit 9 Neighboring gene otospiralin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Collagen9a1c localizes to collagen fibers called actinotrichia in zebrafish fins. Nakagawa H, et al. MicroPubl Biol, 2023. PMID 37090155, Free PMC Article
    2. Differential actinodin1 regulation in zebrafish and mouse appendages. Lalonde RL, et al. Dev Biol, 2016 Sep 1. PMID 27196393
    3. The Physical Role of Mesenchymal Cells Driven by the Actin Cytoskeleton Is Essential for the Orientation of Collagen Fibrils in Zebrafish Fins. Kuroda J, et al. Front Cell Dev Biol, 2020. PMID 33154970, Free PMC Article
    4. Roles of basal keratinocytes in actinotrichia formation. Kuroda J, et al. Mech Dev, 2018 Oct. PMID 30194970
    5. Differential actinodin1 regulation in embryonic development and adult fin regeneration in Danio rerio. Phan HE, et al. PLoS One, 2019. PMID 31048899, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the first non-coding exon and first intron of actinodin1 contains a transcriptional enhancer and an alternative promoter that are necessary for the persistence of reporter expression reminiscent of actinodin1 expression during adulthood.
      Title: Differential actinodin1 regulation in embryonic development and adult fin regeneration in Danio rerio.
    2. fluorescent reporters in transgenic zebrafish identified tissue-specific cis-acting regulatory elements responsible for actinodin1 (and1) expression in the ectodermal and mesenchymal cell populations of the fins, respectively. cells of the mouse limb bud mesoderm do not express the transgene, in contrast to zebrafish, leading to the downregulation and eventual loss of this gene from tetrapod genomes.
      Title: Differential actinodin1 regulation in zebrafish and mouse appendages.
    3. Double gene knockdown of and1 and and2 in zebrafish embryos results in the absence of actinotrichia and impaired fin folds.
      Title: Loss of fish actinotrichia proteins and the fin-to-limb transition.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within cartilage development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within fin development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    actinodin1
    Names
    2-F11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001197254.1 → NP_001184183.1  actinodin1 precursor

      Status: VALIDATED

      Source sequence(s)
      CR450695
      UniProtKB/TrEMBL
      A0A8M1NW68, E7F5V5
      Related
      ENSDARP00000105441.2, ENSDART00000128618.3
      Conserved Domains (1) summary
      PRK14086
      Location:376 → 557
      dnaA; chromosomal replication initiation protein; Provisional

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      26279503..26283359 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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