ptgr1.1 prostaglandin reductase 1, tandem duplicate 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ptgr1.1provided by ZNC
Official Full Name: prostaglandin reductase 1, tandem duplicate 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-041212-80
See related: Ensembl:ENSDARG00000024877 AllianceGenome:ZFIN:ZDB-GENE-041212-80
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ptgr1; ltb4dh; wu:fj35e05; zgc:101689
Summary: Predicted to enable 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity. Predicted to be involved in prostaglandin metabolic process. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be located in cytoplasm. Is expressed in digestive system; nervous system; and pectoral fin. Orthologous to human PTGR1 (prostaglandin reductase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (24376071..24390831, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (24104914..24119674, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity	IBA Inferred from Biological aspect of Ancestor more info
enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity	IEA Inferred from Electronic Annotation more info
enables 2-alkenal reductase [NAD(P)+] activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in prostaglandin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within prostaglandin metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: prostaglandin reductase 1

Names: leukotriene B4 12-hydroxydehydrogenase

NP_001008651.1

EC 1.3.1.74

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008651.1 → NP_001008651.1 prostaglandin reductase 1

See identical proteins and their annotated locations for NP_001008651.1

Status: PROVISIONAL

Source sequence(s)

BC086722

UniProtKB/TrEMBL

Q5PRB9

Related

ENSDARP00000038835.6, ENSDART00000036680.8

Conserved Domains (2) summary

TIGR02825
Location:4 → 328

B4_12hDH; leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase

cd08294
Location:3 → 329

leukotriene_B4_DH_like; 13-PGR is a bifunctional enzyme with delta-13 15-prostaglandin reductase and leukotriene B4 12 hydroxydehydrogenase activity