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    mlst8 MTOR associated protein, LST8 homolog (S. cerevisiae) [ Danio rerio (zebrafish) ]

    Gene ID: 792689, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mlst8provided by ZNC
    Official Full Name
    MTOR associated protein, LST8 homolog (S. cerevisiae)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6176
    See related
    Ensembl:ENSDARG00000003167 AllianceGenome:ZFIN:ZDB-GENE-030131-6176
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    gbl; fi37e04; zgc:55455; zgc:85668; wu:fi37e04
    Summary
    Predicted to be involved in TOR signaling and regulation of actin cytoskeleton organization. Predicted to be located in cytoplasm. Predicted to be part of TORC1 complex and TORC2 complex. Orthologous to human MLST8 (MTOR associated protein, LST8 homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See mlst8 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (18543792..18553114)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (18421918..18431240)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene methionine sulfoxide reductase B1b Neighboring gene meiosis specific with OB-fold Neighboring gene BRICHOS domain containing 5 Neighboring gene phosphoglycolate phosphatase Neighboring gene zinc finger DHHC-type palmitoyltransferase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. CD44a functions as a regulator of p53 signaling, apoptosis and autophagy in the antibacterial immune response. Cao L, et al. Commun Biol, 2022 Aug 30. PMID 36042265, Free PMC Article
    2. Transcriptomic profiling of mTOR and ryanodine receptor signaling molecules in developing zebrafish in the absence and presence of PCB 95. Frank DF, et al. PeerJ, 2017. PMID 29201571, Free PMC Article
    3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC55455, MGC85668

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within TOR signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of TORC1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TORC1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of TORC2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TORC2 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    target of rapamycin complex subunit lst8
    Names
    TORC subunit lst8
    gable
    protein GbetaL

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320388.1 → NP_001307317.1  target of rapamycin complex subunit lst8

      Status: VALIDATED

      Source sequence(s)
      CT009714, EH546936, EH568073
      UniProtKB/Swiss-Prot
      Q803V5
      UniProtKB/TrEMBL
      B2GPI2
      Related
      ENSDARP00000118004.1, ENSDART00000148326.3
      Conserved Domains (3) summary
      COG2319
      Location:10 → 320
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:14 → 297
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:47 → 83
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      18543792..18553114
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394835.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      510166..519488
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_199877.2: Suppressed sequence

      Description
      NM_199877.2: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q803V5.1 GenPept UniProtKB/Swiss-Prot:Q803V5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
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