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    bmp7a bone morphogenetic protein 7a [ Danio rerio (zebrafish) ]

    Gene ID: 30584, updated on 15-Dec-2024

    Summary

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    Official Symbol
    bmp7aprovided by ZNC
    Official Full Name
    bone morphogenetic protein 7aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-000208-25
    See related
    Ensembl:ENSDARG00000018260 AllianceGenome:ZFIN:ZDB-GENE-000208-25
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    bmp7; fb83f09; wu:fb83f09
    Summary
    Enables identical protein binding activity and protein heterodimerization activity. Acts upstream of or within several processes, including BMP signaling pathway; determination of bilateral symmetry; and negative regulation of endodermal cell fate specification. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including forebrain; gastrula cell; margin; prechordal plate; and tail bud. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human BMP7 (bone morphogenetic protein 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See bmp7a in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (7107798..7139545, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (7099493..7129716, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene si:ch211-253b8.5 Neighboring gene uncharacterized LOC101886356 Neighboring gene si:zfos-1451h6.1 Neighboring gene small nucleolar SNORD12/SNORD106 Neighboring gene small nucleolar SNORD12/SNORD106

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of a BMP7 homolog in zebrafish expressed in developing organ systems. Shawi M, et al. Gene Expr Patterns, 2008 Jul. PMID 18602348
    2. Morpholino phenocopies of the bmp2b/swirl and bmp7/snailhouse mutations. Imai Y, et al. Genesis, 2001 Jul. PMID 11477698
    3. BMP7 promotes cardiomyocyte regeneration in zebrafish and adult mice. Bongiovanni C, et al. Cell Rep, 2024 May 28. PMID 38678558
    4. A tale of two receptors: Bmp heterodimers recruit two type I receptors but use the kinase activity of only one. Christian J. Proc Natl Acad Sci U S A, 2021 May 11. PMID 33893177, Free PMC Article
    5. Deficiency of AP1 Complex Ap1g1 in Zebrafish Model Led to Perturbation of Neurodevelopment, Female and Male Fertility; New Insight to Understand Adaptinopathies. Mignani L, et al. Int J Mol Sci, 2023 Apr 12. PMID 37108275, Free PMC Article

    See all (96) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BMP7 promotes cardiomyocyte regeneration in zebrafish and adult mice.
      Title: BMP7 promotes cardiomyocyte regeneration in zebrafish and adult mice.
    2. A tale of two receptors: Bmp heterodimers recruit two type I receptors but use the kinase activity of only one.
      Title: A tale of two receptors: Bmp heterodimers recruit two type I receptors but use the kinase activity of only one.
    3. BMP heterodimers signal via distinct type I receptor class functions.
      Title: BMP heterodimers signal via distinct type I receptor class functions.
    4. these data support a model in which Tfap2a, acting through Bmp7a, modulates Fgf and Notch signaling to control the duration, amount and speed of SAG neural development.
      Title: Tfap2a promotes specification and maturation of neurons in the inner ear through modulation of Bmp, Fgf and notch signaling.
    5. maternally supplied Smad5 is already required to mediate ventral specification prior to zygotic Bmp2/7 signaling to establish the initial dorsoventral asymmetry
      Title: Maternally supplied Smad5 is required for ventral specification in zebrafish embryos prior to zygotic Bmp signaling.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within determination of left/right symmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within determination of ventral identity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within determination of ventral identity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within determination of ventral identity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within dorsal/ventral pattern formation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within dorsal/ventral pattern formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryonic heart tube morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart looping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within locus ceruleus development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of endodermal cell fate specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within post-anal tail morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    bone morphogenetic protein 7a
    Names
    bone morphogenetic protein 7
    snailhouse
    snh

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131321.3 → NP_571396.1  bone morphogenetic protein 7a precursor

      See identical proteins and their annotated locations for NP_571396.1

      Status: VALIDATED

      Source sequence(s)
      CR925817, CU633826
      UniProtKB/TrEMBL
      A0A8N7UZJ1, Q9PTF9
      Related
      ENSDARP00000017352.7, ENSDART00000016472.9
      Conserved Domains (2) summary
      pfam00019
      Location:329 → 431
      TGF_beta; Transforming growth factor beta like domain
      pfam00688
      Location:34 → 275
      TGFb_propeptide; TGF-beta propeptide

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      7107798..7139545 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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