gfm1 G elongation factor, mitochondrial 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gfm1provided by ZNC
Official Full Name: G elongation factor, mitochondrial 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-061013-79
See related: Ensembl:ENSDARG00000063624 AllianceGenome:ZFIN:ZDB-GENE-061013-79
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fc96f12; wu:fc96f12; zgc:154041
Summary: Predicted to enable GTPase activity and translation elongation factor activity. Predicted to be involved in mitochondrial translational elongation. Predicted to act upstream of or within translational elongation. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 1. Orthologous to human GFM1 (G elongation factor mitochondrial 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (1167119..1194750)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (1206316..1233947)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

G45958 (e-PCR)
- UniSTS:106760

fc96f12.x1 (e-PCR)
- UniSTS:194850

fk66c02.x1 (e-PCR)
- UniSTS:201388

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables translation elongation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation elongation factor activity	IEA Inferred from Electronic Annotation more info
enables translation elongation factor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in mitochondrial translational elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial translational elongation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within translational elongation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: elongation factor G, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001079994.1 → NP_001073463.1 elongation factor G, mitochondrial

See identical proteins and their annotated locations for NP_001073463.1

Status: PROVISIONAL

Source sequence(s)

BC124798

UniProtKB/Swiss-Prot

Q08BB1

Related

ENSDARP00000087584.4, ENSDART00000093152.5

Conserved Domains (6) summary

cd01886
Location:43 → 315

EF-G; Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis

PRK12740
Location:47 → 726

PRK12740; elongation factor G; Reviewed

cd01434
Location:519 → 635

EFG_mtEFG1_IV; EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2 ...

cd04097
Location:641 → 718

mtEFG1_C; mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating ...

cd04091
Location:347 → 427

mtEFG1_II_like; Domain II of mitochondrial elongation factor G1-like proteins found in eukaryotes

cd16262
Location:441 → 516

EFG_III; Domain III of Elongation Factor G (EFG)