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    exoc7 exocyst complex component 7 [ Danio rerio (zebrafish) ]

    Gene ID: 406723, updated on 9-Dec-2024

    Summary

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    Official Symbol
    exoc7provided by ZNC
    Official Full Name
    exocyst complex component 7provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2752
    See related
    Ensembl:ENSDARG00000087229 AllianceGenome:ZFIN:ZDB-GENE-040426-2752
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:56575
    Summary
    Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity. Involved in telencephalon development. Predicted to be part of exocyst. Used to study microcephaly. Orthologous to human EXOC7 (exocyst complex component 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See exoc7 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (46696868..46738403)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (46703660..46745179)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 16 Neighboring gene trans-golgi network vesicle protein 23 homolog B (S. cerevisiae) Neighboring gene plasminogen activator, urokinase b Neighboring gene vinculin b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Regulation of human cerebral cortical development by EXOC7 and EXOC8, components of the exocyst complex, and roles in neural progenitor cell proliferation and survival. Coulter ME, et al. Genet Med, 2020 Jun. PMID 32103185, Free PMC Article
    2. Bleb Expansion in Migrating Cells Depends on Supply of Membrane from Cell Surface Invaginations. Goudarzi M, et al. Dev Cell, 2017 Dec 4. PMID 29173819, Free PMC Article
    3. Function-driven discovery of disease genes in zebrafish using an integrated genomics big data resource. Shim H, et al. Nucleic Acids Res, 2016 Nov 16. PMID 27903883, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in telencephalon development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of exocyst IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exocyst IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    exocyst complex component 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213414.1 → NP_998579.1  exocyst complex component 7

      See identical proteins and their annotated locations for NP_998579.1

      Status: PROVISIONAL

      Source sequence(s)
      BC052121
      UniProtKB/Swiss-Prot
      E7FC72
      UniProtKB/TrEMBL
      Q7ZTX5
      Related
      ENSDARP00000106499.1, ENSDART00000123357.4
      Conserved Domains (1) summary
      pfam03081
      Location:308 → 667
      Exo70; Exo70 exocyst complex subunit

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      46696868..46738403
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005172976.5 → XP_005173033.1  exocyst complex component 7 isoform X1

      UniProtKB/Swiss-Prot
      E7FC72
      UniProtKB/TrEMBL
      A0A286Y9B1, A0A8M2BKR1
      Related
      ENSDARP00000143777.1, ENSDART00000174765.2
      Conserved Domains (1) summary
      pfam03081
      Location:321 → 693
      Exo70; Exo70 exocyst complex subunit

    2. XM_005172978.5 → XP_005173035.1  exocyst complex component 7 isoform X4

      UniProtKB/Swiss-Prot
      E7FC72
      UniProtKB/TrEMBL
      A0A8M2BK81
      Conserved Domains (1) summary
      pfam03081
      Location:321 → 680
      Exo70; Exo70 exocyst complex subunit

    3. XM_009306982.4 → XP_009305257.1  exocyst complex component 7 isoform X3

      UniProtKB/Swiss-Prot
      E7FC72
      UniProtKB/TrEMBL
      A0A8M3AYR4
      Conserved Domains (1) summary
      pfam03081
      Location:312 → 684
      Exo70; Exo70 exocyst complex subunit

    4. XM_021480048.2 → XP_021335723.1  exocyst complex component 7 isoform X7

      UniProtKB/Swiss-Prot
      E7FC72
      UniProtKB/TrEMBL
      A0A8M9Q897
      Conserved Domains (1) summary
      pfam03081
      Location:312 → 671
      Exo70; Exo70 exocyst complex subunit

    5. XM_009306981.4 → XP_009305256.1  exocyst complex component 7 isoform X2

      UniProtKB/Swiss-Prot
      E7FC72
      UniProtKB/TrEMBL
      A0A8M3B4X1, U3JAX5
      Related
      ENSDARP00000127396.1, ENSDART00000152928.3
      Conserved Domains (1) summary
      pfam03081
      Location:317 → 689
      Exo70; Exo70 exocyst complex subunit

    6. XM_005172980.5 → XP_005173037.1  exocyst complex component 7 isoform X6

      UniProtKB/Swiss-Prot
      E7FC72
      UniProtKB/TrEMBL
      A0A8M2BK84, U3JB38
      Related
      ENSDARP00000127460.1, ENSDART00000152880.3
      Conserved Domains (1) summary
      pfam03081
      Location:317 → 676
      Exo70; Exo70 exocyst complex subunit

    7. XM_005172979.5 → XP_005173036.1  exocyst complex component 7 isoform X5

      UniProtKB/Swiss-Prot
      E7FC72
      UniProtKB/TrEMBL
      A0A8M2BKA5
      Conserved Domains (1) summary
      pfam03081
      Location:308 → 680
      Exo70; Exo70 exocyst complex subunit

    8. XM_005172981.5 → XP_005173038.1  exocyst complex component 7 isoform X8

      UniProtKB/Swiss-Prot
      E7FC72
      UniProtKB/TrEMBL
      A0A8M2BKR2
      Conserved Domains (1) summary
      pfam03081
      Location:287 → 659
      Exo70; Exo70 exocyst complex subunit

    9. XM_005172982.5 → XP_005173039.1  exocyst complex component 7 isoform X9

      UniProtKB/Swiss-Prot
      E7FC72
      UniProtKB/TrEMBL
      A0A8M2BK98, U3JAN6
      Related
      ENSDARP00000127304.1, ENSDART00000153445.3
      Conserved Domains (1) summary
      pfam03081
      Location:287 → 646
      Exo70; Exo70 exocyst complex subunit

    10. XM_068224536.1 → XP_068080637.1  exocyst complex component 7 isoform X10

      UniProtKB/Swiss-Prot
      E7FC72
      Related
      ENSDARP00000106414.2, ENSDART00000123834.3

    11. XM_005172977.5 → XP_005173034.1  exocyst complex component 7 isoform X11

      UniProtKB/Swiss-Prot
      E7FC72
      UniProtKB/TrEMBL
      A0A2R8QNA9, A0A8M2BK85
      Related
      ENSDARP00000156036.1, ENSDART00000189923.1
      Conserved Domains (1) summary
      pfam03081
      Location:338 → 697
      Exo70; Exo70 exocyst complex subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E7FC72.2 GenPept UniProtKB/Swiss-Prot:E7FC72

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