atp1a1b ATPase Na+/K+ transporting subunit alpha 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: atp1a1bprovided by ZNC
Official Full Name: ATPase Na+/K+ transporting subunit alpha 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-001212-5
See related: Ensembl:ENSDARG00000019856 AllianceGenome:ZFIN:ZDB-GENE-001212-5
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb707; atp1a1l5; atp[a]1B2; zgc:92351; wu:fj34g01
Summary: Predicted to enable P-type sodium:potassium-exchanging transporter activity. Predicted to be involved in intracellular monoatomic cation homeostasis and monoatomic cation transmembrane transport. Predicted to act upstream of or within potassium ion transport and sodium ion transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in central nervous system and neural tube. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2DD. Orthologous to human ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 9

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (35901663..35922188)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (36092478..36113003)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Na+/K+-ATPase alpha1B1 is required for maintaining ventricular cardiomyocyte morphology and viability. Loss results in the mutant "small heart": a small & severely malformed heart & multiple developmental defects of the brain, ears, eyes, & kidneys.
Title: The small heart mutation reveals novel roles of Na+/K+-ATPase in maintaining ventricular cardiomyocyte morphology and viability in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables P-type potassium transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables P-type sodium:potassium-exchanging transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular potassium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular sodium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion export across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sodium ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in sarcolemma	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sodium/potassium-transporting ATPase subunit alpha-1b

Names: ATPase, Na+/K+ transporting, alpha 1 polypeptide like 5; ATPase, Na+/K+ transporting, alpha 1b polypeptide

NP_571765.1

EC 7.2.2.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131690.1 → NP_571765.1 sodium/potassium-transporting ATPase subunit alpha-1b

See identical proteins and their annotated locations for NP_571765.1

Status: PROVISIONAL

Source sequence(s)

AY008375

UniProtKB/TrEMBL

Q9DEU1

Related

ENSDARP00000021569.5, ENSDART00000005086.6

Conserved Domains (6) summary

smart00831
Location:41 → 115

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

COG4087
Location:608 → 754

COG4087; Soluble P-type ATPase [General function prediction only]

TIGR01106
Location:32 → 1025

ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit

pfam00122
Location:135 → 366

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:801 → 1010

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam13246
Location:428 → 523

Cation_ATPase; Cation transport ATPase (P-type)