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    rnmt RNA (guanine-7-) methyltransferase [ Danio rerio (zebrafish) ]

    Gene ID: 562801, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rnmtprovided by ZNC
    Official Full Name
    RNA (guanine-7-) methyltransferaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041008-25
    See related
    Ensembl:ENSDARG00000070553 AllianceGenome:ZFIN:ZDB-GENE-041008-25
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fi09c12; im:6910566; wu:fi09c12; si:ch211-105d11.3
    Summary
    Predicted to enable RNA binding activity and mRNA 5'-cap (guanine-N7-)-methyltransferase activity. Predicted to be involved in 7-methylguanosine mRNA capping. Predicted to act upstream of or within mRNA processing and methylation. Predicted to be part of mRNA cap methyltransferase RNMT:RAMAC complex. Predicted to be active in nucleus. Orthologous to human RNMT (RNA guanine-7 methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See rnmt in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (12649811..12681730)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (12730283..12762202)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor class A domain containing 4a Neighboring gene family with sequence similarity 210 member Aa Neighboring gene uncharacterized LOC137488483 Neighboring gene melanocortin 5a receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables mRNA 5'-cap (guanine-N7-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 5'-cap (guanine-N7-)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 5'-cap (guanine-N7-)-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 7-methylguanosine mRNA capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within 7-methylguanosine mRNA capping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 7-methylguanosine mRNA capping ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mRNA cap methyltransferase RNMT:RAMAC complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    mRNA cap guanine-N(7) methyltransferase
    Names
    RG7MT1
    mRNA (guanine-N(7)-)-methyltransferase
    mRNA cap guanine-N7 methyltransferase
    mRNA cap methyltransferase
    NP_001038465.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045000.1 → NP_001038465.1  mRNA cap guanine-N(7) methyltransferase

      See identical proteins and their annotated locations for NP_001038465.1

      Status: PROVISIONAL

      Source sequence(s)
      AL928820
      UniProtKB/Swiss-Prot
      Q1MTD3
      Related
      ENSDARP00000083350.6, ENSDART00000088917.7
      Conserved Domains (2) summary
      COG0500
      Location:85 → 256
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      pfam03291
      Location:69 → 398
      Pox_MCEL; mRNA capping enzyme

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      12649811..12681730
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q1MTD3.1 GenPept UniProtKB/Swiss-Prot:Q1MTD3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.