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    pak1 p21 protein (Cdc42/Rac)-activated kinase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 373103, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pak1provided by ZNC
    Official Full Name
    p21 protein (Cdc42/Rac)-activated kinase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030826-29
    See related
    Ensembl:ENSDARG00000103959 AllianceGenome:ZFIN:ZDB-GENE-030826-29
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb761; wu:fj97h10
    Summary
    Enables identical protein binding activity and protein kinase activity. Acts upstream of with a positive effect on canonical Wnt signaling pathway. Acts upstream of or within several processes, including bulbus arteriosus development; embryonic organ morphogenesis; and pro-T cell differentiation. Predicted to be active in cytoplasm. Is expressed in several structures, including axial mesoderm; cardiovascular system; nervous system; neural tube; and pectoral fin. Human ortholog(s) of this gene implicated in breast cancer; renal cell carcinoma; and schizophrenia. Orthologous to human PAK1 (p21 (RAC1) activated kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pak1 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (3169897..3284188)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (3268382..3319326, complement)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene chloride channel, nucleotide-sensitive, 1A Neighboring gene aquaporin 11 Neighboring gene uncharacterized LOC137488245 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 4a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development. Lightcap CM, et al. PLoS One, 2009 Jun 26. PMID 19557173, Free PMC Article
    2. A mutation in PAK3 with a dual molecular effect deregulates the RAS/MAPK pathway and drives an X-linked syndromic phenotype. Magini P, et al. Hum Mol Genet, 2014 Jul 1. PMID 24556213
    3. A betaPix Pak2a signaling pathway regulates cerebral vascular stability in zebrafish. Liu J, et al. Proc Natl Acad Sci U S A, 2007 Aug 28. PMID 17573532, Free PMC Article
    4. Pulses of RhoA signaling stimulate actin polymerization and flow in protrusions to drive collective cell migration. Qian W, et al. Curr Biol, 2024 Jan 22. PMID 38096821,
    5. A Pak1/Erk signaling module acts through Gata6 to regulate cardiovascular development in zebrafish. Kelly ML, et al. Dev Cell, 2014 May 12. PMID 24823378, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these data suggest an essential role for Pak1 as an Erk activator, and Gata6 as an Erk target, during neural crest development.
      Title: A Pak1/Erk signaling module acts through Gata6 to regulate cardiovascular development in zebrafish.
    2. Two functional endothelial cell-specific miRNAs, miR-126a and miR-126b, synergistically regulate zebrafish vascular integrity, and pak1 is a critical target of miR-126a/b in vascular development.
      Title: Two functional microRNA-126s repress a novel target gene p21-activated kinase 1 to regulate vascular integrity in zebrafish.
    3. LC8 facilitates nuclear import of Pak1 and this function is indispensable during vertebrate development
      Title: Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within bulbus arteriosus development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_positive_effect canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within convergent extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryonic viscerocranium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart looping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neural crest cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within pro-T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase PAK 1
    Names
    p21/Cdc42/Rac1-activated kinase 1
    NP_958485.1
    XP_021323273.1
    XP_021323274.1
    XP_068070833.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201328.1 → NP_958485.1  serine/threonine-protein kinase PAK 1

      See identical proteins and their annotated locations for NP_958485.1

      Status: PROVISIONAL

      Source sequence(s)
      BC044138
      UniProtKB/TrEMBL
      Q803Z0
      Related
      ENSDARP00000132462.2, ENSDART00000164724.2
      Conserved Domains (3) summary
      smart00220
      Location:302 → 553
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam00786
      Location:73 → 128
      PBD; P21-Rho-binding domain
      cl21453
      Location:281 → 576
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      3169897..3284188
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068214732.1 → XP_068070833.1  serine/threonine-protein kinase PAK 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PFA6

    2. XM_021467598.2 → XP_021323273.1  serine/threonine-protein kinase PAK 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9P9X9
      Conserved Domains (2) summary
      pfam00786
      Location:73 → 130
      PBD; P21-Rho-binding domain
      cl21453
      Location:283 → 586
      PKc_like; Protein Kinases, catalytic domain

    3. XM_021467599.2 → XP_021323274.1  serine/threonine-protein kinase PAK 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PFA6
      Related
      ENSDARP00000132912.2, ENSDART00000166580.2
      Conserved Domains (2) summary
      pfam00786
      Location:73 → 130
      PBD; P21-Rho-binding domain
      cl21453
      Location:283 → 578
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version

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