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    tktb transketolase b [ Danio rerio (zebrafish) ]

    Gene ID: 378713, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tktbprovided by ZNC
    Official Full Name
    transketolase bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030909-13
    See related
    Ensembl:ENSDARG00000006019 AllianceGenome:ZFIN:ZDB-GENE-030909-13
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    tkt; cb860; fb38f03; fj52f12; id:ibd3270; wu:fb38f03; wu:fj52f12; wu:cegs2794
    Summary
    Predicted to enable thiamine pyrophosphate binding activity and transketolase activity. Predicted to be located in cytoplasm. Is expressed in several structures, including alar plate midbrain region; digestive system; eye; midbrain; and yolk. Orthologous to several human genes including TKTL2 (transketolase like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tktb in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (20113378..20126247, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (20187035..20199904, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene si:dkey-32e6.6 Neighboring gene troponin C type 1b (slow) Neighboring gene leucine rich repeat containing 23 Neighboring gene si:dkey-32e6.3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Molecular and functional characterisation of the zebrafish (Danio rerio) PEPT1-type peptide transporter. Verri T, et al. FEBS Lett, 2003 Aug 14. PMID 12914936
    2. Gender-specific proteomic responses in zebrafish liver following exposure to a selected mixture of brominated flame retardants. Kling P, et al. Ecotoxicol Environ Saf, 2008 Oct. PMID 18258299
    3. Dichlorvos exposure results in large scale disruption of energy metabolism in the liver of the zebrafish, Danio rerio. Bui-Nguyen TM, et al. BMC Genomics, 2015 Oct 24. PMID 26499117, Free PMC Article
    4. Analyses of mRNA structure dynamics identify embryonic gene regulatory programs. Beaudoin JD, et al. Nat Struct Mol Biol, 2018 Aug. PMID 30061596, Free PMC Article
    5. The zebrafish lens proteome during development and aging. Greiling TM, et al. Mol Vis, 2009 Nov 13. PMID 19936306, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiamine pyrophosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transketolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transketolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transketolase-like protein 2
    NP_932336.3
    XP_021325435.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198070.3 → NP_932336.3  transketolase-like protein 2

      See identical proteins and their annotated locations for NP_932336.3

      Status: VALIDATED

      Source sequence(s)
      AY422993, BC056536, CD281952
      UniProtKB/TrEMBL
      Q6PHI8, Q6TEQ6
      Related
      ENSDARP00000017569.5, ENSDART00000005021.6
      Conserved Domains (4) summary
      cd07033
      Location:322 → 477
      TPP_PYR_DXS_TK_like; Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins
      PRK05899
      Location:7 → 621
      PRK05899; transketolase; Reviewed
      cd02012
      Location:19 → 273
      TPP_TK; Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the ...
      pfam02780
      Location:493 → 615
      Transketolase_C; Transketolase, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      20113378..20126247 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021469760.2 → XP_021325435.1  transketolase-like protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PWD4
      Conserved Domains (1) summary
      PRK05899
      Location:1 → 575
      PRK05899; transketolase; Reviewed
    Nucleotide Protein Strain
    Heading Accession and Version

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