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    med25 mediator complex subunit 25 [ Danio rerio (zebrafish) ]

    Gene ID: 406793, updated on 9-Dec-2024

    Summary

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    Official Symbol
    med25provided by ZNC
    Official Full Name
    mediator complex subunit 25provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2850
    See related
    Ensembl:ENSDARG00000038005 AllianceGenome:ZFIN:ZDB-GENE-040426-2850
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:63555
    Summary
    Acts upstream of or within roof of mouth development. Predicted to be located in nucleus. Predicted to be part of mediator complex and transcription regulator complex. Is expressed in head; post-vent region; and trunk. Orthologous to several human genes including MED25 (mediator complex subunit 25). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See med25 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (30454353..30488081, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (30323514..30357255, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene myosin binding protein Ca Neighboring gene leucine rich repeat containing 4Ba Neighboring gene zinc finger BED-type containing 4-like 1 Neighboring gene synaptotagmin III Neighboring gene uncharacterized LOC137490622

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Exome Sequence Analysis Suggests that Genetic Burden Contributes to Phenotypic Variability and Complex Neuropathy. Gonzaga-Jauregui C, et al. Cell Rep, 2015 Aug 18. PMID 26257172, Free PMC Article
    2. Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25. Nakamura Y, et al. Nat Commun, 2011. PMID 21427722, Free PMC Article
    3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within roof of mouth development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mediator of RNA polymerase II transcription subunit 25
    Names
    mediator of RNA polymerase II transcription, subunit 25 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214766.2 → NP_999931.1  mediator of RNA polymerase II transcription subunit 25

      See identical proteins and their annotated locations for NP_999931.1

      Status: PROVISIONAL

      Source sequence(s)
      BC058057
      UniProtKB/Swiss-Prot
      Q6PEH8
      Related
      ENSDARP00000055392.5, ENSDART00000055393.7
      Conserved Domains (4) summary
      pfam11232
      Location:395 → 541
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:224 → 325
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11244
      Location:644 → 701
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
      pfam11265
      Location:10 → 222
      Med25_VWA; Mediator complex subunit 25 von Willebrand factor type A

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      30454353..30488081 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009299442.4 → XP_009297717.1  mediator of RNA polymerase II transcription subunit 25 isoform X3

      UniProtKB/TrEMBL
      A0A8M3AQJ9
      Conserved Domains (4) summary
      pfam11232
      Location:395 → 541
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:224 → 325
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11244
      Location:591 → 648
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
      pfam11265
      Location:10 → 222
      Med25_VWA; Mediator complex subunit 25 von Willebrand factor type A

    2. XM_005163940.5 → XP_005163997.1  mediator of RNA polymerase II transcription subunit 25 isoform X2

      UniProtKB/TrEMBL
      A0A8M2BB42, F1R0J2
      Conserved Domains (4) summary
      pfam11232
      Location:395 → 541
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:224 → 325
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11244
      Location:644 → 701
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
      pfam11265
      Location:10 → 222
      Med25_VWA; Mediator complex subunit 25 von Willebrand factor type A

    3. XM_005163937.5 → XP_005163994.1  mediator of RNA polymerase II transcription subunit 25 isoform X1

      See identical proteins and their annotated locations for XP_005163994.1

      UniProtKB/TrEMBL
      A0A8M2BBF9
      Conserved Domains (4) summary
      pfam11232
      Location:395 → 541
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:224 → 325
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11244
      Location:668 → 725
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
      pfam11265
      Location:10 → 222
      Med25_VWA; Mediator complex subunit 25 von Willebrand factor type A

    4. XM_005163938.5 → XP_005163995.1  mediator of RNA polymerase II transcription subunit 25 isoform X1

      See identical proteins and their annotated locations for XP_005163995.1

      UniProtKB/TrEMBL
      A0A8M2BBF9
      Conserved Domains (4) summary
      pfam11232
      Location:395 → 541
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:224 → 325
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11244
      Location:668 → 725
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
      pfam11265
      Location:10 → 222
      Med25_VWA; Mediator complex subunit 25 von Willebrand factor type A

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394533.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      133092..166799 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PEH8.1 GenPept UniProtKB/Swiss-Prot:Q6PEH8

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