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    ppdpfb pancreatic progenitor cell differentiation and proliferation factor b [ Danio rerio (zebrafish) ]

    Gene ID: 336303, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ppdpfbprovided by ZNC
    Official Full Name
    pancreatic progenitor cell differentiation and proliferation factor bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8247
    See related
    Ensembl:ENSDARG00000031317 AllianceGenome:ZFIN:ZDB-GENE-030131-8247
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:73395; c20orf149b; c20orf149l; wu:fj62f01
    Summary
    Predicted to act upstream of or within cell differentiation. Is expressed in mucus secreting cell; nervous system; pancreatic system; and pronephric duct. Orthologous to human PPDPF (pancreatic progenitor cell differentiation and proliferation factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ppdpfb in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (17427838..17429740, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (17501495..17503397, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene PTK6 protein tyrosine kinase 6b Neighboring gene uncharacterized LOC101885965 Neighboring gene transfer RNA glutamic acid (anticodon CUC) Neighboring gene tpd52 like 2b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Exdpf is a key regulator of exocrine pancreas development controlled by retinoic acid and ptf1a in zebrafish. Jiang Z, et al. PLoS Biol, 2008 Nov 25. PMID 19067490, Free PMC Article
    2. A single-cell atlas of de novo β-cell regeneration reveals the contribution of hybrid β/δ-cells to diabetes recovery in zebrafish. Singh SP, et al. Development, 2022 Jan 15. PMID 35088828
    3. H3K27me3-mediated silencing of structural genes is required for zebrafish heart regeneration. Ben-Yair R, et al. Development, 2019 Oct 9. PMID 31427288, Free PMC Article
    4. A δ-cell subpopulation with a pro-β-cell identity contributes to efficient age-independent recovery in a zebrafish model of diabetes. Carril Pardo CA, et al. Elife, 2022 Jan 21. PMID 35060900, Free PMC Article
    5. Transcriptome analysis of pancreatic cells across distant species highlights novel important regulator genes. Tarifeño-Saldivia E, et al. BMC Biol, 2017 Mar 21. PMID 28327131, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pancreatic progenitor cell differentiation and proliferation factor B
    Names
    chromosome 20 open reading frame 149, like
    endocrine differentiation and proliferation factor
    endpf
    exocrine differentiation and proliferation factor B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200008.1 → NP_956302.1  pancreatic progenitor cell differentiation and proliferation factor B

      See identical proteins and their annotated locations for NP_956302.1

      Status: PROVISIONAL

      Source sequence(s)
      BC059699
      UniProtKB/Swiss-Prot
      Q6PBI2
      Related
      ENSDARP00000043075.4, ENSDART00000043076.5
      Conserved Domains (1) summary
      pfam15060
      Location:1 → 106
      PPDFL; Differentiation and proliferation regulator

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      17427838..17429740 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PBI2.1 GenPept UniProtKB/Swiss-Prot:Q6PBI2

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