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    dram2b DNA-damage regulated autophagy modulator 2b [ Danio rerio (zebrafish) ]

    Gene ID: 415225, updated on 9-Dec-2024

    Summary

    Official Symbol
    dram2bprovided by ZNC
    Official Full Name
    DNA-damage regulated autophagy modulator 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040625-141
    See related
    Ensembl:ENSDARG00000044241 AllianceGenome:ZFIN:ZDB-GENE-040625-141
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    dram2; fj35e01; zgc:86754; wu:fj35e01
    Summary
    Predicted to be involved in photoreceptor cell maintenance and regulation of autophagy. Predicted to be located in membrane. Predicted to be active in lysosome. Human ortholog(s) of this gene implicated in cone-rod dystrophy 21. Orthologous to human DRAM2 (DNA damage regulated autophagy modulator 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See dram2b in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (856869..866203, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (839975..849318, complement)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene zgc:153675 Neighboring gene cryptochrome circadian regulator 4 Neighboring gene DENN/MADD domain containing 2Db Neighboring gene choline/ethanolamine phosphotransferase 1b Neighboring gene serine/threonine kinase 38b

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in photoreceptor cell maintenance  
    involved_in regulation of autophagy  
    Component Evidence Code Pubs
    is_active_in lysosome  
    located_in membrane  

    General protein information

    Preferred Names
    DNA damage-regulated autophagy modulator protein 2b
    Names
    DNA-damage regulated autophagy modulator 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002135.2 → NP_001002135.2  DNA damage-regulated autophagy modulator protein 2b

      Status: VALIDATED

      Source sequence(s)
      CU855600
      UniProtKB/TrEMBL
      Q6IQI0
      Related
      ENSDARP00000119947.1, ENSDART00000146619.2

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      856869..866203 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005168271.5 → XP_005168328.1  DNA damage-regulated autophagy modulator protein 2b isoform X1

      UniProtKB/TrEMBL
      A0A8M2BFL3, F1R7U0, Q6IQI0
      Conserved Domains (1) summary
      pfam10277
      Location:8 → 235
      Frag1; Frag1/DRAM/Sfk1 family
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