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    bag4 BCL2 associated athanogene 4 [ Danio rerio (zebrafish) ]

    Gene ID: 100001980, updated on 9-Dec-2024

    Summary

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    Official Symbol
    bag4provided by ZNC
    Official Full Name
    BCL2 associated athanogene 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5484
    See related
    Ensembl:ENSDARG00000043179 AllianceGenome:ZFIN:ZDB-GENE-030131-5484
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fd20a04; wu:fd20a04; si:dkey-220o5.3
    Summary
    Predicted to enable adenyl-nucleotide exchange factor activity and protein-folding chaperone binding activity. Predicted to be involved in protein stabilization. Predicted to be active in cytosol; membrane; and nucleus. Orthologous to human BAG4 (BAG cochaperone 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See bag4 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (44599408..44611274, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (44605502..44617368, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene si:dkey-220o5.5 Neighboring gene radial spoke head 14 homolog Neighboring gene LSM1, U6 small nuclear RNA associated Neighboring gene G protein-coupled receptor kinase 5 like Neighboring gene uncharacterized LOC137496384

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. On the origin of BAG(3) and its consequences for an expansion of BAG3's role in protein homeostasis. Baeken MW, et al. J Cell Biochem, 2022 Jan. PMID 33942360
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables adenyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    BAG family molecular chaperone regulator 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256729.2 → NP_001243658.1  BAG family molecular chaperone regulator 4

      Status: PROVISIONAL

      Source sequence(s)
      EH536056, EH564466
      UniProtKB/TrEMBL
      A0A8M1P3L3, B8JJ17
      Related
      ENSDARP00000063395.6, ENSDART00000063396.7
      Conserved Domains (1) summary
      smart00264
      Location:321 → 398
      BAG; BAG domains, present in regulator of Hsp70 proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      44599408..44611274 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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