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    trmt5 tRNA methyltransferase 5 [ Danio rerio (zebrafish) ]

    Gene ID: 564078, updated on 27-Dec-2024

    Summary

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    Official Symbol
    trmt5provided by ZNC
    Official Full Name
    tRNA methyltransferase 5provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5978
    See related
    Ensembl:ENSDARG00000069278 AllianceGenome:ZFIN:ZDB-GENE-030131-5978
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fi28b08
    Summary
    Predicted to enable tRNA methyltransferase activity. Predicted to be involved in mitochondrial tRNA methylation and tRNA N1-guanine methylation. Predicted to act upstream of or within methylation and tRNA processing. Predicted to be located in mitochondrion and nucleus. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 26. Orthologous to human TRMT5 (tRNA methyltransferase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See trmt5 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (31681988..31687925, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (31551510..31566334, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene SIX homeobox 4a Neighboring gene MNAT1 component of CDK activating kinase Neighboring gene solute carrier family 38 member 6 Neighboring gene protein kinase C, eta, a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolutionary comparison reveals that diverging CTCF sites are signatures of ancestral topological associating domains borders. Gómez-Marín C, et al. Proc Natl Acad Sci U S A, 2015 Jun 16. PMID 26034287, Free PMC Article
    2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (guanine(37)-N1)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA N1-guanine methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within tRNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tRNA (guanine(37)-N(1))-methyltransferase
    Names
    TRM5 tRNA methyltransferase 5 homolog
    tRNA (guanine-N(1)-)-methyltransferase
    NP_001139055.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145583.1 → NP_001139055.1  tRNA (guanine(37)-N(1))-methyltransferase

      See identical proteins and their annotated locations for NP_001139055.1

      Status: PROVISIONAL

      Source sequence(s)
      BX537123
      UniProtKB/Swiss-Prot
      B8A5G9
      UniProtKB/TrEMBL
      A0A8M3AZ45
      Related
      ENSDARP00000080424.4, ENSDART00000085989.5
      Conserved Domains (2) summary
      pfam02475
      Location:183 → 384
      Met_10; Met-10+ like-protein
      pfam12847
      Location:282 → 343
      Methyltransf_18; Methyltransferase domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      31681988..31687925 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B8A5G9.1 GenPept UniProtKB/Swiss-Prot:B8A5G9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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