tubb2b tubulin, beta 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tubb2bprovided by ZNC
Official Full Name: tubulin, beta 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-722
See related: Ensembl:ENSDARG00000098591 AllianceGenome:ZFIN:ZDB-GENE-030131-722
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb40f09; wu:fb40f09; zgc:123194
Summary: Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to act upstream of or within microtubule-based process. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm and microtubule. Human ortholog(s) of this gene implicated in Leber congenital amaurosis with early-onset deafness and complex cortical dysplasia with other brain malformations 7. Orthologous to several human genes including TUBB4B (tubulin beta 4B class IVb). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 8

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (52713232..52715911, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (52726939..52729618, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

fc74h03.x1 (e-PCR)
- UniSTS:194438

AI461316 (e-PCR)
- UniSTS:206553

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables structural constituent of cytoskeleton	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within microtubule-based process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tubulin beta-2b chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037410.2 → NP_001032487.2 tubulin beta-2b chain

Status: VALIDATED

Source sequence(s)

CU984584

UniProtKB/TrEMBL

A0A8M1N7Z8

Related

ENSDARP00000137515.1, ENSDART00000168241.2

Conserved Domains (2) summary

PLN00220
Location:28 → 457

PLN00220; tubulin beta chain; Provisional

cd02187
Location:29 → 453

beta_tubulin; The beta-tubulin family