fam49a family with sequence similarity 49 member A [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fam49aprovided by ZNC
Official Full Name: family with sequence similarity 49 member Aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-031002-50
See related: Ensembl:ENSDARG00000006672 AllianceGenome:ZFIN:ZDB-GENE-031002-50
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: znf395; fam49ab; sb:cb866; zgc:55309; si:ch211-89p3.1; si:ch211-223o11.1
Summary: Predicted to enable small GTPase binding activity. Acts upstream of or within regulation of T cell differentiation and thymus development. Predicted to be located in membrane. Is expressed in several structures, including adaxial cell; digestive system; musculature system; sensory system; and trunk. Orthologous to human CYRIA (CYFIP related Rac1 interactor A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 20

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (35255403..35298023)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (35352557..35395144)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ndrg1b and fam49ab are 2 new modulators of PTEN signaling that control lymphoid differentiation in the zebrafish thymus.
Title: Ndrg1b and fam49ab modulate the PTEN pathway to control T-cell lymphopoiesis in the zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of T cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of actin filament polymerization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within thymus development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: uncharacterized protein LOC378872

Names: zinc finger protein 395

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.