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    ppp1r15a protein phosphatase 1, regulatory subunit 15A [ Danio rerio (zebrafish) ]

    Gene ID: 797943, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ppp1r15aprovided by ZNC
    Official Full Name
    protein phosphatase 1, regulatory subunit 15Aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-4408
    See related
    Ensembl:ENSDARG00000069135 AllianceGenome:ZFIN:ZDB-GENE-030131-4408
    Gene type
    protein coding
    RefSeq status
    PREDICTED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fd02c11; zgc:162126
    Summary
    Predicted to enable protein phosphatase regulator activity. Predicted to be involved in response to endoplasmic reticulum stress. Predicted to be part of protein phosphatase type 1 complex. Predicted to be active in endoplasmic reticulum. Is expressed in rhombomere and tegmentum. Orthologous to human PPP1R15A (protein phosphatase 1 regulatory subunit 15A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ppp1r15a in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (71504095..71509438)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (71262954..71268297)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene aconitase 1, soluble Neighboring gene leucine-rich melanocyte differentiation-associated protein Neighboring gene alkaline ceramidase 2 Neighboring gene thymidylate synthetase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Loss of the novel Vcp (valosin containing protein) interactor Washc4 interferes with autophagy-mediated proteostasis in striated muscle and leads to myopathy in vivo. Kustermann M, et al. Autophagy, 2018. PMID 30010465, Free PMC Article
    2. Dose-dependent effects of gamma radiation on the early zebrafish development and gene expression. Hurem S, et al. PLoS One, 2017. PMID 28628668, Free PMC Article
    3. Down-Regulation of hspb9 and hspb11 Contributes to Wavy Notochord in Zebrafish Embryos Following Exposure to Polychlorinated Diphenylsulfides. Zhang R, et al. Environ Sci Technol, 2018 Nov 6. PMID 30335980
    4. Slc38a9 Deficiency Induces Apoptosis and Metabolic Dysregulation and Leads to Premature Death in Zebrafish. Wu X, et al. Int J Mol Sci, 2022 Apr 11. PMID 35457018, Free PMC Article
    5. Parental exposure to gamma radiation causes progressively altered transcriptomes linked to adverse effects in zebrafish offspring. Hurem S, et al. Environ Pollut, 2018 Mar. PMID 29248853

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC162126

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to endoplasmic reticulum stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase 1 regulatory subunit 15A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082921.1 → NP_001076390.1  protein phosphatase 1 regulatory subunit 15A

      See identical proteins and their annotated locations for NP_001076390.1

      Status: PREDICTED

      Source sequence(s)
      BC133878
      UniProtKB/TrEMBL
      A0A8M1NC13, A3KNJ7
      Related
      ENSDARP00000091169.2, ENSDART00000100396.5

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      71504095..71509438
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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