pi4k2a phosphatidylinositol 4-kinase type 2 alpha [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pi4k2aprovided by ZNC
Official Full Name: phosphatidylinositol 4-kinase type 2 alphaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2675
See related: Ensembl:ENSDARG00000033666 AllianceGenome:ZFIN:ZDB-GENE-040426-2675
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: pi4kii; zgc:63646; wu:fc84f05; pi4kII alpha
Summary: Predicted to enable 1-phosphatidylinositol 4-kinase activity; AP-3 adaptor complex binding activity; and ATP binding activity. Predicted to be involved in Golgi organization; endosome organization; and phosphatidylinositol phosphate biosynthetic process. Predicted to act upstream of or within lipid metabolic process and phosphorylation. Predicted to be located in several cellular components, including growing cell tip; membrane raft; and presynaptic membrane. Predicted to be part of BLOC-1 complex. Predicted to be active in endosome; plasma membrane; and trans-Golgi network. Orthologous to human PI4K2A (phosphatidylinositol 4-kinase type 2 alpha). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (54737353..54755556)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (54059755..54077905)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

fc84f05.x1 (e-PCR)
- UniSTS:194632

fc03e06.x1 (e-PCR)
- UniSTS:192116

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol 4-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol 4-kinase activity	IEA Inferred from Electronic Annotation more info
enables 1-phosphatidylinositol 4-kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables AP-3 adaptor complex binding	ISS Inferred from Sequence or Structural Similarity more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Golgi organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosome organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylinositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol phosphate biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of BLOC-1 complex	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in growing cell tip	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in neuron projection	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in presynaptic membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in synapse	IEA Inferred from Electronic Annotation more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: phosphatidylinositol 4-kinase type 2-alpha

Names: PI4KII-alpha; phosphatidylinositol 4-kinase II alpha; phosphatidylinositol 4-kinase type II; phosphatidylinositol 4-kinase type II-alpha

NP_998523.1

EC 2.7.1.67

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213358.2 → NP_998523.1 phosphatidylinositol 4-kinase type 2-alpha

See identical proteins and their annotated locations for NP_998523.1

Status: VALIDATED

Source sequence(s)

AL929041, BX119918

UniProtKB/Swiss-Prot

A5PF25, Q52PF3, Q6PE18

Related

ENSDARP00000112458.2, ENSDART00000130675.4

Conserved Domains (2) summary

PHA02777
Location:20 → 87

PHA02777; major capsid L1 protein; Provisional

pfam00454
Location:102 → 397

PI3_PI4_kinase; Phosphatidylinositol 3- and 4-kinase