f11r.1 F11 receptor, tandem duplicate 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: f11r.1provided by ZNC
Official Full Name: F11 receptor, tandem duplicate 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-2416
See related: Ensembl:ENSDARG00000017320 AllianceGenome:ZFIN:ZDB-GENE-030131-2416
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: JAM; f11r; jam1a; wu:fc07c05; zgc:103642
Summary: Enables protein heterodimerization activity. Acts upstream of or within hematopoietic or lymphoid organ development; posterior lateral line development; and regulation of hematopoietic stem cell differentiation. Predicted to be located in plasma membrane. Predicted to be active in bicellular tight junction. Is expressed in several structures, including EVL; digestive system; integument; pronephros; and sensory system. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human F11R (F11 receptor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (29831256..29848772)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (29231253..29248433)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results indicate that Jam1a-Jam2a interactions facilitate the transduction of requisite Notch signals from the somite to the precursors of HSCs, and that these events occur well before formation of the dorsal aorta
Title: Jam1a-Jam2a interactions regulate haematopoietic stem cell fate through Notch signalling.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI626248 (e-PCR)
- UniSTS:206143

fc07c05.x1 (e-PCR)
- UniSTS:187715

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in establishment of endothelial intestinal barrier	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hematopoietic or lymphoid organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intestinal absorption	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within posterior lateral line development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of hematopoietic stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of membrane permeability	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in bicellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: F11 receptor, tandem duplicate 1

Names: jama

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004667.3 → NP_001004667.1 F11 receptor, tandem duplicate 1 precursor

See identical proteins and their annotated locations for NP_001004667.1

Status: PROVISIONAL

Source sequence(s)

CU458900

UniProtKB/TrEMBL

A4JYH9, Q66I72

Related

ENSDARP00000099952.2, ENSDART00000109660.4

Conserved Domains (3) summary

cd00096
Location:139 → 210

Ig; Immunoglobulin domain

smart00410
Location:25 → 118

IG_like; Immunoglobulin like

cl11960
Location:22 → 119

Ig; Immunoglobulin domain