U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    dlgap5 discs, large (Drosophila) homolog-associated protein 5 [ Danio rerio (zebrafish) ]

    Gene ID: 447853, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    dlgap5provided by ZNC
    Official Full Name
    discs, large (Drosophila) homolog-associated protein 5provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040912-160
    See related
    Ensembl:ENSDARG00000045167 AllianceGenome:ZFIN:ZDB-GENE-040912-160
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    dlg7; cb647; sb:cb647; zgc:92146; wu:fc96g08; wu:fe11c02
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including centrosome localization; kinetochore assembly; and mitotic spindle organization. Predicted to act upstream of or within signaling. Predicted to be active in cytoplasm; nucleus; and spindle pole centrosome. Is expressed in brain; head; otic vesicle; pectoral fin musculature; and proliferative region. Orthologous to human DLGAP5 (DLG associated protein 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See dlgap5 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (17633508..17655668, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (17511480..17533804, complement)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 42 Neighboring gene eukaryotic translation initiation factor 2-alpha kinase 1 Neighboring gene PMS1 homolog 2, mismatch repair system component Neighboring gene radial spoke head 10 homolog B Neighboring gene CCZ1 homolog, vacuolar protein trafficking and biogenesis associated Neighboring gene parvalbumin 9

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Genetic evidence for shared mechanisms of epimorphic regeneration in zebrafish. Qin Z, et al. Proc Natl Acad Sci U S A, 2009 Jun 9. PMID 19474300, Free PMC Article
    2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in centrosome localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in kinetochore assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in spindle pole centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    disks large-associated protein 5
    Names
    discs, large homolog 7

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004592.1 → NP_001004592.1  disks large-associated protein 5

      See identical proteins and their annotated locations for NP_001004592.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081607
      UniProtKB/TrEMBL
      Q66HZ9
      Related
      ENSDARP00000066410.5, ENSDART00000066411.7
      Conserved Domains (1) summary
      pfam03359
      Location:360 → 505
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      17633508..17655668 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005169455.5 → XP_005169512.1  disks large-associated protein 5 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BGU9
      Conserved Domains (1) summary
      pfam03359
      Location:360 → 505
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394834.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      77639..100424 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools