fbp1b fructose-1,6-bisphosphatase 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fbp1bprovided by ZNC
Official Full Name: fructose-1,6-bisphosphatase 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-021206-11
See related: Ensembl:ENSDARG00000020364 AllianceGenome:ZFIN:ZDB-GENE-021206-11
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fbp1; cb598; fb17g10; fb57b01; zgc:64127; id:ibd1091; wu:fb17g10; wu:fb57b01
Summary: Predicted to enable fructose 1,6-bisphosphate 1-phosphatase activity. Acts upstream of or within cellular response to estrogen stimulus. Predicted to be active in cytosol. Is expressed in several structures, including digestive system; margin; pronephric duct; yolk; and yolk syncytial layer. Human ortholog(s) of this gene implicated in fructose-1,6-bisphosphatase deficiency. Orthologous to human FBP1 (fructose-bisphosphatase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (35458240..35462118)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (34858087..34861965)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb57b01.x1 (e-PCR)
- UniSTS:190752

fc73a10.x1 (e-PCR)
- UniSTS:194380

fb57b01 (e-PCR)
- UniSTS:187223

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables fructose 1,6-bisphosphate 1-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fructose 1,6-bisphosphate 1-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoric ester hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to estrogen stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in fructose 1,6-bisphosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fructose 6-phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fructose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in gluconeogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within gluconeogenesis	IEA Inferred from Electronic Annotation more info
involved_in gluconeogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fructose-1,6-bisphosphatase 1b

Names: fructose-1,6-bisphosphatase 1

NP_998297.1

EC 3.1.3.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213132.1 → NP_998297.1 fructose-1,6-bisphosphatase 1b

See identical proteins and their annotated locations for NP_998297.1

Status: PROVISIONAL

Source sequence(s)

BC053267

UniProtKB/TrEMBL

A0A8M1PEL5, Q7T337

Related

ENSDARP00000051312.5, ENSDART00000051313.7

Conserved Domains (1) summary

cd00354
Location:18 → 332

FBPase; Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1, ...