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    mfsd14a1 major facilitator superfamily domain containing 14A 1 [ Danio rerio (zebrafish) ]

    Gene ID: 406848, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mfsd14a1provided by ZNC
    Official Full Name
    major facilitator superfamily domain containing 14A 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2935
    See related
    Ensembl:ENSDARG00000043055 AllianceGenome:ZFIN:ZDB-GENE-040426-2935
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    hiat1; hiat1b; zgc:55324; wu:fc64d02; wu:fi04d02; wu:fi11d05
    Summary
    Predicted to enable transmembrane transporter activity. Acts upstream of or within ammonium excretion. Predicted to be located in membrane. Is expressed in several structures, including digestive system; heart; nervous system; pectoral fin bud; and solid lens vesicle. Orthologous to human MFSD14A (major facilitator superfamily domain containing 14A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See mfsd14a1 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (10713711..10735252)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (10684029..10705570)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene hyaluronidase 2b Neighboring gene abhydrolase domain containing 14A Neighboring gene SAS-6 centriolar assembly protein Neighboring gene LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Characterization of two novel ammonia transporters, Hiat1a and Hiat1b, in the teleost model system Danio rerio. Zhouyao H, et al. J Exp Biol, 2022 Oct 15. PMID 36124551
    2. Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression. Perland E, et al. Open Biol, 2017 Sep. PMID 28878041, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within ammonium excretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    MFSD14 family MFS transporter
    Names
    hippocampus abundant transcript 1b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213527.2 → NP_998692.2  MFSD14 family MFS transporter

      Status: VALIDATED

      Source sequence(s)
      BX908398, EH497588
      UniProtKB/TrEMBL
      A0A8M1PFD4, Q1LV45
      Related
      ENSDARP00000105716.2, ENSDART00000122349.4
      Conserved Domains (2) summary
      cd06174
      Location:38 → 395
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:40 → 384
      MFS_1; Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      10713711..10735252
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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