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    abcd3a ATP-binding cassette, sub-family D (ALD), member 3a [ Danio rerio (zebrafish) ]

    Gene ID: 406803, updated on 9-Dec-2024

    Summary

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    Official Symbol
    abcd3aprovided by ZNC
    Official Full Name
    ATP-binding cassette, sub-family D (ALD), member 3aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2868
    See related
    Ensembl:ENSDARG00000104085 AllianceGenome:ZFIN:ZDB-GENE-040426-2868
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb59g09; fd60b04; zgc:55740; wu:fb59g09; wu:fd60b04
    Summary
    Predicted to enable ATP binding activity; ATPase-coupled transmembrane transporter activity; and long-chain fatty acid transmembrane transporter activity. Predicted to be involved in fatty acid catabolic process; long-chain fatty acid import into peroxisome; and peroxisome organization. Predicted to act upstream of or within transmembrane transport. Predicted to be located in membrane and peroxisome. Predicted to be active in peroxisomal membrane. Human ortholog(s) of this gene implicated in Zellweger syndrome and congenital bile acid synthesis defect 5. Orthologous to human ABCD3 (ATP binding cassette subfamily D member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See abcd3a in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (31310640..31332087, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (31373429..31394876, complement)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene coagulation factor IIIa Neighboring gene acid phosphatase 5b, tartrate resistant Neighboring gene family with sequence similarity 168 member B Neighboring gene cAMP responsive element modulator b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Enoyl-CoA hydratase/3-hydroxyacyl CoA dehydrogenase is essential for the production of DHA in zebrafish. Yang G, et al. J Lipid Res, 2023 Mar. PMID 36592657, Free PMC Article
    2. Evolution of the vertebrate ABC gene family: analysis of gene birth and death. Annilo T, et al. Genomics, 2006 Jul. PMID 16631343
    3. Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates. Dean M, et al. Annu Rev Genomics Hum Genet, 2005. PMID 16124856
    4. Genome-wide analysis of the ATP-binding cassette (ABC) transporter gene family in sea lamprey and Japanese lamprey. Ren J, et al. BMC Genomics, 2015 Jun 6. PMID 26047617, Free PMC Article
    5. Functional Characterization and Expression Analyses Show Differential Roles of Maternal and Zygotic Dgcr8 in Early Embryonic Development. Zhu Z, et al. Front Genet, 2020. PMID 32296464, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables long-chain fatty acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables long-chain fatty acid transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty acid import into peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within long-chain fatty acid import into peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peroxisome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in very long-chain fatty acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP-binding cassette sub-family D member 3a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213482.1 → NP_998647.1  ATP-binding cassette sub-family D member 3a

      See identical proteins and their annotated locations for NP_998647.1

      Status: PROVISIONAL

      Source sequence(s)
      BC044468
      UniProtKB/TrEMBL
      Q803I6
      Related
      ENSDARP00000138371.1, ENSDART00000161179.2
      Conserved Domains (3) summary
      cd03223
      Location:437 → 642
      ABCD_peroxisomal_ALDP; ATP-binding cassette domain of peroxisomal transporter, subfamily D
      TIGR00954
      Location:1 → 644
      3a01203; Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein
      pfam06472
      Location:58 → 337
      ABC_membrane_2; ABC transporter transmembrane region 2

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      31310640..31332087 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021470125.2 → XP_021325800.1  ATP-binding cassette sub-family D member 3a isoform X1

      UniProtKB/TrEMBL
      A0A8M9PXC6
      Conserved Domains (1) summary
      TIGR00954
      Location:1 → 644
      3a01203; Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395182.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      138973..160023 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395367.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      140369..164922 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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