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    mat2b methionine adenosyltransferase 2 non-catalytic beta subunit methionine [ Danio rerio (zebrafish) ]

    Gene ID: 541347, updated on 4-Jan-2025

    Summary

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    Official Symbol
    mat2bprovided by ZNC
    Official Full Name
    methionine adenosyltransferase 2 non-catalytic beta subunit methionineprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-786
    See related
    Ensembl:ENSDARG00000012932 AllianceGenome:ZFIN:ZDB-GENE-030131-786
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc55d01; wu:fb48h02; wu:fc55d01; zgc:110308
    Summary
    Predicted to enable methionine adenosyltransferase regulator activity. Predicted to be involved in S-adenosylmethionine biosynthetic process. Predicted to act upstream of or within one-carbon metabolic process. Predicted to be part of methionine adenosyltransferase complex. Is expressed in anterior neural tube and optic cup. Orthologous to human MAT2B (methionine adenosyltransferase 2 non-catalytic beta subunit). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See mat2b in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (32065316..32082130, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (32032046..32048872, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene zgc:165573 Neighboring gene si:ch211-160j14.2 Neighboring gene uncharacterized LOC100333843 Neighboring gene transfer RNA valine (anticodon AAC) Neighboring gene transfer RNA valine (anticodon CAC)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Embryo Microinjection of Selenomethionine Reduces Hatchability and Modifies Oxidant Responsive Gene Expression in Zebrafish. Thomas JK, et al. Sci Rep, 2016 May 23. PMID 27210033, Free PMC Article
    2. Disruption of the folate pathway in zebrafish causes developmental defects. Lee MS, et al. BMC Dev Biol, 2012 Apr 5. PMID 22480165, Free PMC Article
    3. A comparative map of the zebrafish genome. Woods IG, et al. Genome Res, 2000 Dec. PMID 11116086, Free PMC Article
    4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables methionine adenosyltransferase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methionine adenosyltransferase regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in S-adenosylmethionine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in S-adenosylmethionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in S-adenosylmethionine biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within one-carbon metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of methionine adenosyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of methionine adenosyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    methionine adenosyltransferase 2 subunit beta
    Names
    MAT II beta
    methionine adenosyltransferase II, beta
    NP_001013492.2
    XP_005161452.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013474.2 → NP_001013492.2  methionine adenosyltransferase 2 subunit beta

      Status: VALIDATED

      Source sequence(s)
      EB966609, EH549300, EH566280, EH580990
      UniProtKB/Swiss-Prot
      Q5BJJ6
      UniProtKB/TrEMBL
      A0A8M1N4G7, F1RDD5
      Related
      ENSDARP00000016566.6, ENSDART00000003978.9
      Conserved Domains (2) summary
      cd05254
      Location:19 → 305
      dTDP_HR_like_SDR_e; dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs
      pfam04321
      Location:20 → 311
      RmlD_sub_bind; RmlD substrate binding domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      32065316..32082130 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005161395.5 → XP_005161452.1  methionine adenosyltransferase 2 subunit beta isoform X1

      UniProtKB/Swiss-Prot
      Q5BJJ6
      UniProtKB/TrEMBL
      A0A8M2B8C1, E9QCP2
      Related
      ENSDARP00000123222.1, ENSDART00000135659.2
      Conserved Domains (2) summary
      cd05254
      Location:30 → 316
      dTDP_HR_like_SDR_e; dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs
      pfam04321
      Location:31 → 322
      RmlD_sub_bind; RmlD substrate binding domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BJJ6.1 GenPept UniProtKB/Swiss-Prot:Q5BJJ6

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