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    ola1 Obg-like ATPase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 326864, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ola1provided by ZNC
    Official Full Name
    Obg-like ATPase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5063
    See related
    Ensembl:ENSDARG00000044565 AllianceGenome:ZFIN:ZDB-GENE-030131-5063
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fe36h01; zgc:55768; zgc:85691; wu:fc66b09; wu:fe36h01; wu:fk82a02
    Summary
    Predicted to enable ATP hydrolysis activity. Predicted to be located in nucleolus. Predicted to be active in cytoplasm. Orthologous to human OLA1 (Obg like ATPase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ola1 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (10741266..10753507, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (10505839..10518080, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene si:dkey-34m19.3 Neighboring gene Sp3b transcription factor Neighboring gene G protein-coupled receptor 155b Neighboring gene WAS/WASL interacting protein family, member 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal large subunit binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    obg-like ATPase 1
    NP_001268915.1
    NP_999865.1
    XP_021332461.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001281986.1 → NP_001268915.1  obg-like ATPase 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      BX936397, CT720868, EH542806, EH578941, EH611446
      UniProtKB/TrEMBL
      A0A0R4ICN9, A0A8M1P632
      Related
      ENSDARP00000130715.1, ENSDART00000165645.2
      Conserved Domains (3) summary
      cd01900
      Location:25 → 255
      YchF; YchF GTPase
      PTZ00258
      Location:1 → 343
      PTZ00258; GTP-binding protein; Provisional
      pfam06071
      Location:257 → 340
      YchF-GTPase_C; Protein of unknown function (DUF933)

    2. NM_214700.2 → NP_999865.1  obg-like ATPase 1 isoform 1

      See identical proteins and their annotated locations for NP_999865.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      BX936397, EH542806, EH578941, EH611446
      UniProtKB/Swiss-Prot
      Q7ZU42
      Related
      ENSDARP00000045298.7, ENSDART00000045299.9
      Conserved Domains (3) summary
      cd01900
      Location:25 → 303
      YchF; YchF GTPase
      PTZ00258
      Location:1 → 391
      PTZ00258; GTP-binding protein; Provisional
      pfam06071
      Location:305 → 388
      YchF-GTPase_C; Protein of unknown function (DUF933)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      10741266..10753507 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021476786.2 → XP_021332461.1  obg-like ATPase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9QA62
      Conserved Domains (1) summary
      PTZ00258
      Location:6 → 396
      PTZ00258; GTP-binding protein; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7ZU42.1 GenPept UniProtKB/Swiss-Prot:Q7ZU42

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.