U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    pla2g6 phospholipase A2, group VI (cytosolic, calcium-independent) [ Danio rerio (zebrafish) ]

    Gene ID: 406370, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    pla2g6provided by ZNC
    Official Full Name
    phospholipase A2, group VI (cytosolic, calcium-independent)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2079
    See related
    Ensembl:ENSDARG00000060921 AllianceGenome:ZFIN:ZDB-GENE-040426-2079
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:77476; wu:fc06g09
    Summary
    Predicted to enable calcium-independent phospholipase A2 activity and long-chain fatty acyl-CoA hydrolase activity. Predicted to be involved in cardiolipin acyl-chain remodeling and positive regulation of ceramide biosynthetic process. Predicted to act upstream of or within lipid metabolic process. Predicted to be active in mitochondrion. Is expressed in several structures, including eye; heart; liver; muscle; and ovary. Human ortholog(s) of this gene implicated in dystonia 12; neuroaxonal dystrophy; and neurodegenerative disease (multiple). Orthologous to human PLA2G6 (phospholipase A2 group VI). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See pla2g6 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (29087454..29126878)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (29138202..29177683)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene Pim proto-oncogene, serine/threonine kinase, related 100 Neighboring gene chromobox homolog 6a Neighboring gene BAR/IMD domain containing adaptor protein 2 like 2b Neighboring gene parvalbumin 7 Neighboring gene neutrophil cytosolic factor 4

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. PLA2G6 mutations cause motor dysfunction phenotypes of young-onset dystonia-parkinsonism type 14 and can be relieved by DHA treatment in animal models. Yeh TH, et al. Exp Neurol, 2021 Dec. PMID 34520727
    2. Chlorella diet alters mitochondrial cardiolipin contents differentially in organs of Danio rerio analyzed by a lipidomics approach. Chao YJ, et al. PLoS One, 2018. PMID 29494608, Free PMC Article
    3. Zebrafish (Danio rerio) fed vitamin E-deficient diets produce embryos with increased morphologic abnormalities and mortality. Miller GW, et al. J Nutr Biochem, 2012 May. PMID 21684137, Free PMC Article
    4. Triclosan regulates alternative splicing events of nerve-related genes through RNA-binding protein CELF2 to induce zebrafish neurotoxicity. Wang D, et al. J Hazard Mater, 2021 Jul 5. PMID 33621777
    5. Pla2g6 Deficiency in Zebrafish Leads to Dopaminergic Cell Death, Axonal Degeneration, Increased β-Synuclein Expression, and Defects in Brain Functions and Pathways. Sánchez E, et al. Mol Neurobiol, 2018 Aug. PMID 29344929

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pla2g6 deficiency resulted in axonal degeneration, dopaminergic and motor neuron cell loss, and increased beta-synuclein expression.
      Title: Pla2g6 Deficiency in Zebrafish Leads to Dopaminergic Cell Death, Axonal Degeneration, Increased β-Synuclein Expression, and Defects in Brain Functions and Pathways.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium-independent phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    85/88 kDa calcium-independent phospholipase A2
    NP_998262.1
    XP_021324985.1
    XP_068072372.1
    XP_068072373.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213097.2 → NP_998262.1  85/88 kDa calcium-independent phospholipase A2

      See identical proteins and their annotated locations for NP_998262.1

      Status: PROVISIONAL

      Source sequence(s)
      BC067375
      UniProtKB/TrEMBL
      A0A8M2B8Y5, F1QXU0, Q6NWY0
      Related
      ENSDARP00000044558.4, ENSDART00000044559.6
      Conserved Domains (5) summary
      cd07212
      Location:467 → 805
      Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
      cd00204
      Location:145 → 271
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:155 → 247
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:120 → 171
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:151 → 182
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      29087454..29126878
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068216271.1 → XP_068072372.1  85/88 kDa calcium-independent phospholipase A2 isoform X2

      UniProtKB/TrEMBL
      A0A8M2B8Y5, F1QXU0
      Related
      ENSDARP00000143464.1, ENSDART00000178615.2

    2. XM_021469310.2 → XP_021324985.1  85/88 kDa calcium-independent phospholipase A2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PJI1, A0A8M9PV82
      Conserved Domains (3) summary
      cd07212
      Location:473 → 786
      Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
      cd00204
      Location:151 → 277
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:157 → 188
      ANK; ANK repeat [structural motif]

    3. XM_068216272.1 → XP_068072373.1  85/88 kDa calcium-independent phospholipase A2 isoform X3

      UniProtKB/TrEMBL
      A0A8M9PRQ9

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395117.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      53464..98846
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.