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    tmc4 transmembrane channel-like 4 [ Danio rerio (zebrafish) ]

    Gene ID: 100333974, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tmc4provided by ZNC
    Official Full Name
    transmembrane channel-like 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-7489
    See related
    Ensembl:ENSDARG00000031757 AllianceGenome:ZFIN:ZDB-GENE-030131-7489
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj21b01; wu:fb14c11; wu:fj21b01
    Summary
    Predicted to enable mechanosensitive monoatomic ion channel activity. Predicted to be located in plasma membrane. Orthologous to several human genes including TMC4 (transmembrane channel like 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See tmc4 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (32029069..32049732)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (32074988..32096123)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase kappa 1 Neighboring gene glutathione S-transferase kappa 4 Neighboring gene membrane bound O-acyltransferase domain containing 7 Neighboring gene leukocyte receptor cluster (LRC) member 1 Neighboring gene lemur tyrosine kinase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables mechanosensitive monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane channel-like protein 7; voltage-gated chloride channel TMC4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      32029069..32049732
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002664937.6 → XP_002664983.1  voltage-gated chloride channel TMC4

      UniProtKB/TrEMBL
      A0A8M1RE27, E7F4Y3
      Related
      ENSDARP00000041053.7, ENSDART00000041054.9
      Conserved Domains (1) summary
      pfam07810
      Location:461 → 561
      TMC; TMC domain
    Nucleotide Protein
    Heading Accession and Version

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