ctnnb2 catenin, beta 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ctnnb2provided by ZNC
Official Full Name: catenin, beta 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2575
See related: Ensembl:ENSDARG00000023472 AllianceGenome:ZFIN:ZDB-GENE-040426-2575
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ich; zgc:65770; wu:fa12h09; wu:fc16f05
Summary: Enables transcription coregulator activity. Involved in canonical Wnt signaling pathway and determination of dorsal identity. Acts upstream of or within convergent extension and dorsal/ventral axis specification. Located in nucleus. Is expressed in corneal endothelium; lateral line system; oocyte; unfertilized egg; and vertebral column. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant intellectual developmental disorder 19; exudative vitreoretinopathy 7; hepatocellular carcinoma (multiple); reproductive organ cancer (multiple); and urinary system cancer (multiple). Orthologous to human CTNNB1 (catenin beta 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 19

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (47975912..47997424, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (48311965..48346965, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	Unplaced Scaffold	NW_008805477.1 (867..1885, complement)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ctnnb1 and ctnnb2 regulate multiple processes of laterality development in zebrafish embryos through similar and distinct mechanisms.
Title: β-Catenin 1 and β-catenin 2 play similar and distinct roles in left-right asymmetric development of zebrafish embryos.
We demonstrate that amotl2 knockdown in zebrafish wild-type embryos results in embryonic dorsalization, and this effect can be antagonized by co-knockdown of the dorsal inducer beta-catenin2.
Title: The Amotl2 gene inhibits Wnt/β-catenin signaling and regulates embryonic development in zebrafish.
Foxo3b played a very important role in embryogenesis and negatively regulated maternal and zygotic Wnt/beta-catenin signaling by directly interacting with both beta-catenin1 and beta-catenin2.
Title: Zebrafish foxo3b negatively regulates canonical Wnt signaling to affect early embryogenesis.
Downregulation of beta-catenin gene may cause omphalocele in the Cd chick model by disrupting CRT-mediated Ca(2+) signaling and AJs.
Title: Disruption of calreticulin-mediated cellular adhesion signaling in the cadmium-induced omphalocele in the chick model.
ctnnb1 and ctnnb2 have essential and opposing roles in the formation of dorsal axial structures and neuroectoderm.
Title: Essential and opposing roles of zebrafish beta-catenins in the formation of dorsal axial structures and neurectoderm.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fd99b02.y1 (e-PCR)
- UniSTS:195854

fa12h09.s1 (e-PCR)
- UniSTS:202357

G47962 (e-PCR)
- UniSTS:108728

fk20e12.y1 (e-PCR)
- UniSTS:200640

G45408 (e-PCR)
- UniSTS:106210

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables alpha-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cadherin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cadherin binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coregulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription coregulator activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in animal organ development	IEA Inferred from Electronic Annotation more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within convergent extension	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of dorsal identity	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within determination of dorsal identity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of dorsal identity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dorsal/ventral axis specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
part_of catenin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: catenin, beta 2

Names: beta-catenin 2; ichabod

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001889.1 → NP_001001889.1 catenin, beta 2

See identical proteins and their annotated locations for NP_001001889.1

Status: PROVISIONAL

Source sequence(s)

AF329680

UniProtKB/TrEMBL

Q8JID2

Related

ENSDARP00000076115.5, ENSDART00000081675.6

Conserved Domains (3) summary

smart00185
Location:349 → 389

ARM; Armadillo/beta-catenin-like repeats

cd00020
Location:398 → 517

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:401 → 426

ARM; armadillo repeat [structural motif]