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    chga chromogranin A [ Danio rerio (zebrafish) ]

    Gene ID: 450039, updated on 9-Dec-2024

    Summary

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    Official Symbol
    chgaprovided by ZNC
    Official Full Name
    chromogranin Aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041010-161
    See related
    Ensembl:ENSDARG00000008829 AllianceGenome:ZFIN:ZDB-GENE-041010-161
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj05f09; zgc:56075; wu:fj05f09; zgc:101749; si:dkey-177p2.2
    Summary
    Predicted to be involved in adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation; defense response to bacterium; and negative regulation of secretion by cell. Predicted to be located in extracellular region; secretory granule; and transport vesicle. Predicted to be active in chromaffin granule and extracellular space. Is expressed in nervous system; otic vesicle; trigeminal placode; and trunk neural crest. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; end stage renal disease; hypertension; and prostate cancer. Orthologous to human CHGA (chromogranin A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See chga in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (27020201..27046006)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (27121105..27146916)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene SEL1L adaptor subunit of SYVN1 ubiquitin ligase Neighboring gene si:dkey-177p2.18 Neighboring gene inositol-tetrakisphosphate 1-kinase a Neighboring gene transmembrane protein 251

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Targeted expression of human MYCN selectively causes pancreatic neuroendocrine tumors in transgenic zebrafish. Yang HW, et al. Cancer Res, 2004 Oct 15. PMID 15492244
    2. Zebrafish model of KRAS-initiated pancreatic endocrine tumor. Oh S, et al. Anim Cells Syst (Seoul), 2019 Jun. PMID 31231585, Free PMC Article
    3. Spatio-temporal expression of chromogranin A during zebrafish embryogenesis. Xie J, et al. J Endocrinol, 2008 Sep. PMID 18586978
    4. Knockdown of Carboxypeptidase A6 in Zebrafish Larvae Reduces Response to Seizure-Inducing Drugs and Causes Changes in the Level of mRNAs Encoding Signaling Molecules. Lopes MW, et al. PLoS One, 2016. PMID 27050163, Free PMC Article
    5. Biological Activity of Porcine Gastric Mucin on Stress Resistance and Immunomodulation. Liyanage TD, et al. Molecules, 2020 Jun 29. PMID 32610600, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of catecholamine secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of insulin secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chromaffin granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in secretory granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in transport vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    chromogranin-A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006059.2 → NP_001006059.2  chromogranin-A precursor

      Status: VALIDATED

      Source sequence(s)
      BX248515, CK027054, DT865424, EH463078
      UniProtKB/TrEMBL
      A0A8M1N2U5, Q5RIJ8
      Related
      ENSDARP00000022142.5, ENSDART00000016014.6
      Conserved Domains (1) summary
      pfam01271
      Location:34 → 339
      Granin; Granin (chromogranin or secretogranin)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      27020201..27046006
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005160561.5 → XP_005160618.1  chromogranin-A isoform X1

      UniProtKB/TrEMBL
      A0A8M2B7N6
      Conserved Domains (1) summary
      pfam01271
      Location:34 → 338
      Granin; Granin (chromogranin or secretogranin)
    Nucleotide Protein Strain
    Heading Accession and Version

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