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    arrb2a arrestin, beta 2a [ Danio rerio (zebrafish) ]

    Gene ID: 321378, updated on 9-Dec-2024

    Summary

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    Official Symbol
    arrb2aprovided by ZNC
    Official Full Name
    arrestin, beta 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-29
    See related
    Ensembl:ENSDARG00000039215 AllianceGenome:ZFIN:ZDB-GENE-030131-29
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc14e09; zeh0294; zgc:66353; hm:zeh0294; wu:fc14e09
    Summary
    Predicted to enable angiotensin receptor binding activity. Acts upstream of or within regulation of chemokine activity and regulation of receptor recycling. Predicted to be active in cytoplasm. Is expressed in presumptive segmental plate; somite; and tail bud. Human ortholog(s) of this gene implicated in glioblastoma; heroin dependence; nicotine dependence; and opiate dependence. Orthologous to human ARRB2 (arrestin beta 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See arrb2a in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (22891147..22907418)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (22921674..22938135)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene actinodin3 Neighboring gene adaptor related protein complex 4 subunit mu 1 Neighboring gene si:ch1073-143l10.2 Neighboring gene mediator complex subunit 11 Neighboring gene ribonuclease, RNase K b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. β-arrestin control of late endosomal sorting facilitates decoy receptor function and chemokine gradient formation. Mahabaleshwar H, et al. Development, 2012 Aug. PMID 22791893
    2. Cone arrestin confers cone vision of high temporal resolution in zebrafish larvae. Renninger SL, et al. Eur J Neurosci, 2011 Feb. PMID 21299656
    3. On the origins of arrestin and rhodopsin. Alvarez CE. BMC Evol Biol, 2008 Jul 29. PMID 18664266, Free PMC Article
    4. Induction of cardiac dysfunction in developing and adult zebrafish by chronic isoproterenol stimulation. Kossack M, et al. J Mol Cell Cardiol, 2017 Jul. PMID 28554511
    5. Comparative analysis of period genes in teleost fish genomes. Wang H. J Mol Evol, 2008 Jul. PMID 18535754

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables angiotensin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor internalization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of chemokine activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of receptor recycling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    arrestin, beta 2a
    Names
    ARRB2b1
    arrestin beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214681.1 → NP_999846.1  arrestin, beta 2a

      See identical proteins and their annotated locations for NP_999846.1

      Status: PROVISIONAL

      Source sequence(s)
      BC057519
      UniProtKB/TrEMBL
      Q6PFK2
      Related
      ENSDARP00000057290.4, ENSDART00000057291.5
      Conserved Domains (2) summary
      smart01017
      Location:194 → 349
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      pfam00339
      Location:19 → 175
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      22891147..22907418
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068223725.1 → XP_068079826.1  arrestin, beta 2a isoform X2

    2. XM_009305269.4 → XP_009303544.1  arrestin, beta 2a isoform X1

      UniProtKB/TrEMBL
      A0A286YBG8, A0A8M3AWN0
      Related
      ENSDARP00000144541.1, ENSDART00000176011.2
      Conserved Domains (2) summary
      smart01017
      Location:194 → 357
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      pfam00339
      Location:19 → 175
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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