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    klf7b Kruppel like factor 7b [ Danio rerio (zebrafish) ]

    Gene ID: 553082, updated on 9-Dec-2024

    Summary

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    Official Symbol
    klf7bprovided by ZNC
    Official Full Name
    Kruppel like factor 7bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041014-171
    See related
    Ensembl:ENSDARG00000043821 AllianceGenome:ZFIN:ZDB-GENE-041014-171
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    klf7l; zgc:153366; si:dkey-101c24.1
    Summary
    Enables cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within optic nerve formation. Is expressed in nervous system; neural rod; and trigeminal placode. Orthologous to human KLF7 (KLF transcription factor 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See klf7b in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (28344497..28399071, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (28533751..28588325, complement)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene cyclin Y-like 1 Neighboring gene cAMP responsive element binding protein 1b Neighboring gene si:ch73-7i4.1 Neighboring gene uncharacterized LOC101884404

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Krüpple-like factors 7 and 6a mRNA expression in adult zebrafish central nervous system. Bhattarai S, et al. Gene Expr Patterns, 2016 May. PMID 27364471, Free PMC Article
    2. Tuba1a gene expression is regulated by KLF6/7 and is necessary for CNS development and regeneration in zebrafish. Veldman MB, et al. Mol Cell Neurosci, 2010 Apr. PMID 20123021, Free PMC Article
    3. Gene expression analysis of zebrafish retinal ganglion cells during optic nerve regeneration identifies KLF6a and KLF7a as important regulators of axon regeneration. Veldman MB, et al. Dev Biol, 2007 Dec 15. PMID 17949705
    4. Characterization and phylogenetic analysis of Krüppel-like transcription factor (KLF) gene family in tree shrews (Tupaia belangeri chinensis). Shao M, et al. Oncotarget, 2017 Mar 7. PMID 28032601, Free PMC Article
    5. Jak/Stat signaling stimulates zebrafish optic nerve regeneration and overcomes the inhibitory actions of Socs3 and Sfpq. Elsaeidi F, et al. J Neurosci, 2014 Feb 12. PMID 24523552, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within optic nerve formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Krueppel-like factor 7b
    Names
    Kruppel-like factor 7 (ubiquitous), like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044766.2 → NP_001038231.1  Krueppel-like factor 7b

      See identical proteins and their annotated locations for NP_001038231.1

      Status: PROVISIONAL

      Source sequence(s)
      BC124329
      UniProtKB/TrEMBL
      B2GS50, Q5TYN4
      Related
      ENSDARP00000095092.2, ENSDART00000104317.5
      Conserved Domains (3) summary
      COG5048
      Location:205 → 277
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:214 → 236
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:258 → 283
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      28344497..28399071 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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