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    zgc:171426 zgc:171426 [ Danio rerio (zebrafish) ]

    Gene ID: 100137103, updated on 9-Dec-2024

    Summary

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    Official Symbol
    zgc:171426provided by ZNC
    Official Full Name
    zgc:171426provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080212-2
    See related
    AllianceGenome:ZFIN:ZDB-GENE-080212-2
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in nervous system development. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in otitis media. Orthologous to human A2ML1 (alpha-2-macroglobulin like 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See zgc:171426 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (3469597..3481763)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (3687360..3699511)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene si:dkey-46g23.5 Neighboring gene zgc:165453 Neighboring gene zmp:0000000896 Neighboring gene CDC42 effector protein (Rho GTPase binding) 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pregnancy zone protein; uncharacterized protein LOC100137103

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      3469597..3481763
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017354907.3 → XP_017210396.1  pregnancy zone protein

      UniProtKB/TrEMBL
      A0A8M6YXV1
      Conserved Domains (7) summary
      COG2373
      Location:148 → 1086
      YfaS; Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only]
      cd02897
      Location:977 → 1252
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:759 → 847
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:147 → 239
      A2M_N; MG2 domain
      pfam07677
      Location:1372 → 1461
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:1029 → 1252
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:484 → 628
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001114700.1: Suppressed sequence

      Description
      NM_001114700.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from cow: A2M (GeneID:513856).
    Nucleotide Protein Strain
    Heading Accession and Version

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