mep1a.1 meprin A, alpha (PABA peptide hydrolase), tandem duplicate 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mep1a.1provided by ZNC
Official Full Name: meprin A, alpha (PABA peptide hydrolase), tandem duplicate 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-041001-209
See related: Ensembl:ENSDARG00000029747 AllianceGenome:ZFIN:ZDB-GENE-041001-209
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: MEP1A; si:dkey-30j22.7
Summary: Predicted to enable metalloendopeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be located in membrane. Is expressed in several structures, including brush border epithelial cell; digestive system; epidermis; gill; and heart. Orthologous to human MEP1A (meprin A subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 20

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (35473288..35481584)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (35570409..35578705)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Danio rerio appears to be a suitable model to gain insight into the basic physiological functions of meprin metalloproteases
Title: Two alpha subunits and one beta subunit of meprin zinc-endopeptidases are differentially expressed in the zebrafish Danio rerio.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: meprin A, alpha (PABA peptide hydrolase), tandem duplicate 1

Names: MEP1Aa; meprin A, alpha, tandem duplicate 1; meprin A, alpha.1

NP_001025452.1

EC 3.4.24.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001030281.2 → NP_001025452.1 meprin A, alpha (PABA peptide hydrolase), tandem duplicate 1 precursor

See identical proteins and their annotated locations for NP_001025452.1

Status: PROVISIONAL

Source sequence(s)

BC115219

UniProtKB/TrEMBL

A4FUN0, Q5RHM1

Related

ENSDARP00000047194.4, ENSDART00000047195.6

Conserved Domains (5) summary

cd06263
Location:261 → 419

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

pfam00629
Location:261 → 420

MAM; MAM domain, meprin/A5/mu

pfam01400
Location:65 → 253

Astacin; Astacin (Peptidase family M12A)

cl00064
Location:26 → 251

ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

cl02446
Location:419 → 582

MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...