apoc2 apolipoprotein C-II [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: apoc2provided by ZNC
Official Full Name: apolipoprotein C-IIprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-2168
See related: Ensembl:ENSDARG00000092155 AllianceGenome:ZFIN:ZDB-GENE-030131-2168
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb71a04; fb98g08; wu:fb52e03; wu:fb71a04; wu:fb98g08
Summary: Predicted to enable phospholipase activator activity and phospholipase binding activity. Acts upstream of or within definitive hemopoiesis; lipid metabolic process; and lipoprotein catabolic process. Predicted to be located in extracellular region. Predicted to be part of several cellular components, including low-density lipoprotein particle; spherical high-density lipoprotein particle; and triglyceride-rich plasma lipoprotein particle. Is expressed in intestine; liver; pancreas; and yolk. Used to study familial hyperlipidemia; familial lipoprotein lipase deficiency; and hyperlipoproteinemia type IV. Human ortholog(s) of this gene implicated in familial apolipoprotein C-II deficiency; familial hyperlipidemia; and multiple sclerosis. Orthologous to human APOC2 (apolipoprotein C2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (23984755..23991161)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (24069723..24076129)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the apoc2 mutant zebrafish is a robust and versatile animal model to study hypertriglyceridemia.
Title: Apoc2 loss-of-function zebrafish mutant as a genetic model of hyperlipidemia.

Submit: New GeneRIF Correction

General gene information

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Markers

fb52e03.x1 (e-PCR)
- UniSTS:203287

fb71a04.x1 (e-PCR)
- UniSTS:191041

fb98g08.x1 (e-PCR)
- UniSTS:203622

AI477362 (e-PCR)
- UniSTS:206480

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables enzyme activator activity	IEA Inferred from Electronic Annotation more info
enables phospholipase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chylomicron remnant clearance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within definitive hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in high-density lipoprotein particle clearance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in lipoprotein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipoprotein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipoprotein transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of chylomicron	IBA Inferred from Biological aspect of Ancestor more info
part_of chylomicron	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
part_of high-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
part_of intermediate-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info
part_of low-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info
part_of low-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
part_of spherical high-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info
part_of very-low-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info
part_of very-low-density lipoprotein particle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: apolipoprotein C-II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.