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    ccdc61 coiled-coil domain containing 61 [ Danio rerio (zebrafish) ]

    Gene ID: 798766, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ccdc61provided by ZNC
    Official Full Name
    coiled-coil domain containing 61provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060929-348
    See related
    Ensembl:ENSDARG00000062307 AllianceGenome:ZFIN:ZDB-GENE-060929-348
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:153153
    Summary
    Enables identical protein binding activity. Predicted to be involved in centriole assembly and mitotic spindle assembly. Predicted to act upstream of or within cell projection organization. Predicted to be located in centriolar satellite. Predicted to be part of centriolar subdistal appendage. Predicted to be active in ciliary basal body. Orthologous to human CCDC61 (coiled-coil domain containing 61). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ccdc61 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (21263967..21277833)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (21227341..21241197)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene RPTOR independent companion of MTOR, complex 2b Neighboring gene LIF receptor subunit alpha b Neighboring gene inositol-trisphosphate 3-kinase Ca Neighboring gene uncharacterized LOC101882370

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. CCDC61/VFL3 Is a Paralog of SAS6 and Promotes Ciliary Functions. Ochi T, et al. Structure, 2020 Jun 2. PMID 32375023, Free PMC Article
    2. Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Raman R, et al. Sci Rep, 2021 Jul 27. PMID 34315984, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC153153, MGC173475

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables identical protein binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centriole assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitotic spindle assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of centriolar subdistal appendage ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary basal body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein CCDC61
    Names
    VFL3 homolog
    coiled-coil domain-containing protein 61

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077166.1 → NP_001070634.1  centrosomal protein CCDC61

      See identical proteins and their annotated locations for NP_001070634.1

      Status: PROVISIONAL

      Source sequence(s)
      BC124262
      UniProtKB/Swiss-Prot
      Q08CF3
      Related
      ENSDARP00000084084.5, ENSDART00000089651.7
      Conserved Domains (1) summary
      TIGR02168
      Location:147 → 384
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      21263967..21277833
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005161214.5 → XP_005161271.1  centrosomal protein CCDC61 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B871, F1QJ08
      Related
      ENSDARP00000098205.3, ENSDART00000108978.4
      Conserved Domains (1) summary
      TIGR02168
      Location:147 → 378
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08CF3.1 GenPept UniProtKB/Swiss-Prot:Q08CF3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.