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    pmpca peptidase, mitochondrial processing subunit alpha [ Danio rerio (zebrafish) ]

    Gene ID: 492801, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pmpcaprovided by ZNC
    Official Full Name
    peptidase, mitochondrial processing subunit alphaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5809
    See related
    Ensembl:ENSDARG00000102607 AllianceGenome:ZFIN:ZDB-GENE-030131-5809
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fi19e06; wu:fj83d11; zgc:101647
    Summary
    Predicted to enable metal ion binding activity and metalloendopeptidase activity. Predicted to be involved in protein processing involved in protein targeting to mitochondrion. Predicted to act upstream of or within proteolysis. Predicted to be active in mitochondrion. Is expressed in several structures, including alar plate midbrain region; anterior neural keel; head; immature eye; and optic tectum. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 2. Orthologous to human PMPCA (peptidase, mitochondrial processing subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pmpca in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (65040237..65062719)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (64351240..64373722)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene annexin A1c Neighboring gene annexin A1b Neighboring gene inositol polyphosphate-5-phosphatase E Neighboring gene peptidyl-tRNA hydrolase 1 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Intrinsic myocardial defects underlie an Rbfox-deficient zebrafish model of hypoplastic left heart syndrome. Huang M, et al. Nat Commun, 2022 Oct 5. PMID 36198703, Free PMC Article
    2. Characterization of retinoid-X receptor genes rxra, rxrba, rxrbb and rxrg during zebrafish development. Tallafuss A, et al. Gene Expr Patterns, 2006 Jun. PMID 16448862
    3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein processing involved in protein targeting to mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial-processing peptidase subunit alpha
    Names
    peptidase (mitochondrial processing) alpha
    NP_001007443.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007442.1 → NP_001007443.1  mitochondrial-processing peptidase subunit alpha

      See identical proteins and their annotated locations for NP_001007443.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085400
      UniProtKB/TrEMBL
      Q5U3T6
      Related
      ENSDARP00000132105.1, ENSDART00000164278.2
      Conserved Domains (3) summary
      COG0612
      Location:59 → 496
      PqqL; Predicted Zn-dependent peptidase [General function prediction only]
      pfam00675
      Location:69 → 218
      Peptidase_M16; Insulinase (Peptidase family M16)
      pfam05193
      Location:224 → 423
      Peptidase_M16_C; Peptidase M16 inactive domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      65040237..65062719
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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