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    arhgef28a Rho guanine nucleotide exchange factor (GEF) 28a [ Danio rerio (zebrafish) ]

    Gene ID: 559941, updated on 9-Dec-2024

    Summary

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    Official Symbol
    arhgef28aprovided by ZNC
    Official Full Name
    Rho guanine nucleotide exchange factor (GEF) 28aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060531-28
    See related
    Ensembl:ENSDARG00000060415 AllianceGenome:ZFIN:ZDB-GENE-060531-28
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    rgnef; arhgef28; p190RhoGEF; si:ch211-1o14.5
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and metal ion binding activity. Acts upstream of or within Golgi organization; cell-matrix adhesion; and muscle tissue morphogenesis. Predicted to be located in cytoplasm. Is expressed in ball; head; notochord; somite; and trunk. Orthologous to human ARHGEF28 (Rho guanine nucleotide exchange factor 28). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See arhgef28a in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (34829723..34964822, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (34229423..34364648, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene ectodermal-neural cortex 1 Neighboring gene uncharacterized LOC137495608 Neighboring gene ankyrin repeat, family A (RFXANK-like), 2 Neighboring gene basic transcription factor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of novel MYO18A interaction partners required for myoblast adhesion and muscle integrity. Cao JM, et al. Sci Rep, 2016 Nov 8. PMID 27824130, Free PMC Article
    2. Transcriptome analysis reveals positive selection on the divergent between topmouth culter and zebrafish. Ren L, et al. Gene, 2014 Dec 1. PMID 25267534
    3. The guanine nucleotide exchange factor Net1 facilitates the specification of dorsal cell fates in zebrafish embryos by promoting maternal β-catenin activation. Wei S, et al. Cell Res, 2017 Feb. PMID 27910850, Free PMC Article
    4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within muscle tissue morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within muscle tissue morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rho-guanine nucleotide exchange factor; rho guanine nucleotide exchange factor 28
    Names
    Rho guanine nucleotide exchange factor (GEF) 28
    Rho-guanine nucleotide exchange factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      34829723..34964822 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068221454.1 → XP_068077555.1  rho guanine nucleotide exchange factor 28 isoform X3

      UniProtKB/TrEMBL
      A0A8M9PL62

    2. XM_021476534.2 → XP_021332209.1  rho guanine nucleotide exchange factor 28 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PL62, A0A8M9Q486, F6P6M2
      Related
      ENSDARP00000116715.2, ENSDART00000133170.3
      Conserved Domains (4) summary
      cd00029
      Location:716 → 761
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:910 → 1104
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00204
      Location:229 → 283
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14680
      Location:1148 → 1248
      PH_p190RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain

    3. XM_021476533.2 → XP_021332208.1  rho guanine nucleotide exchange factor 28 isoform X4

      UniProtKB/TrEMBL
      A0A8M6YZA7, A0A8M9PYS9
      Conserved Domains (4) summary
      cd00029
      Location:745 → 790
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:939 → 1133
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00204
      Location:229 → 283
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14680
      Location:1177 → 1277
      PH_p190RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain

    4. XM_021476529.2 → XP_021332204.1  rho guanine nucleotide exchange factor 28 isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q483, A0A8M9QEQ0
      Conserved Domains (4) summary
      cd00029
      Location:779 → 824
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:973 → 1167
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00204
      Location:229 → 283
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14680
      Location:1211 → 1311
      PH_p190RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394590.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      139078..276236 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068218239.1 → XP_068074340.1  rho guanine nucleotide exchange factor 28 isoform X3

      UniProtKB/TrEMBL
      A0A8M6YZA7

    2. XM_068218238.1 → XP_068074339.1  rho guanine nucleotide exchange factor 28 isoform X7

      UniProtKB/TrEMBL
      A0A8M9PL62

    3. XM_009301598.4 → XP_009299873.2  rho guanine nucleotide exchange factor 28 isoform X5

      UniProtKB/TrEMBL
      A0A8M3ASG5, A0A8M9QEQ0
      Conserved Domains (4) summary
      cd00029
      Location:772 → 817
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:966 → 1160
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00204
      Location:229 → 283
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14680
      Location:1204 → 1304
      PH_p190RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain

    4. XM_017356272.3 → XP_017211761.2  rho guanine nucleotide exchange factor 28 isoform X2

      UniProtKB/TrEMBL
      A0A8M6YZA7, A0A8M6Z0T3
      Conserved Domains (4) summary
      cd00029
      Location:716 → 761
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:910 → 1104
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00204
      Location:229 → 283
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14680
      Location:1148 → 1248
      PH_p190RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain

    5. XM_017356270.3 → XP_017211759.2  rho guanine nucleotide exchange factor 28 isoform X6

      UniProtKB/TrEMBL
      A0A8M6Z6H3, A0A8M9PL62
      Conserved Domains (4) summary
      cd00029
      Location:750 → 795
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:944 → 1138
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00204
      Location:229 → 283
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14680
      Location:1182 → 1282
      PH_p190RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain

    6. XM_017356269.3 → XP_017211758.2  rho guanine nucleotide exchange factor 28 isoform X1

      UniProtKB/TrEMBL
      A0A8M6YYE7, A0A8M9QEQ0
      Conserved Domains (4) summary
      cd00029
      Location:779 → 824
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:973 → 1167
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00204
      Location:229 → 283
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14680
      Location:1211 → 1311
      PH_p190RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain
    Nucleotide Protein Strain
    Heading Accession and Version

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