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    ksr1b kinase suppressor of ras 1b [ Danio rerio (zebrafish) ]

    Gene ID: 556779, updated on 27-Dec-2024

    Summary

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    Official Symbol
    ksr1bprovided by ZNC
    Official Full Name
    kinase suppressor of ras 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040724-45
    See related
    Ensembl:ENSDARG00000030933 AllianceGenome:ZFIN:ZDB-GENE-040724-45
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    dZ122B7.1; si:busm1-122b7.1; si:ch211-237d5.6
    Summary
    Predicted to enable ATP binding activity; metal ion binding activity; and protein serine/threonine kinase activity. Predicted to act upstream of or within protein phosphorylation. Human ortholog(s) of this gene implicated in breast adenocarcinoma. Orthologous to human KSR1 (kinase suppressor of ras 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ksr1b in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (31071276..31147269, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (31189819..31266527, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene lectin, galactoside-binding, soluble, 9 (galectin 9)-like 1 Neighboring gene lectin, galactoside-binding, soluble, 9 (galectin 9)-like 3 Neighboring gene WD repeat and SOCS box containing 1 Neighboring gene CUE domain containing 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Galectins in channel catfish, Ictalurus punctatus: Characterization and expression profiling in mucosal tissues. Zhou S, et al. Fish Shellfish Immunol, 2016 Feb. PMID 26767746
    2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kinase suppressor of Ras 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      31071276..31147269 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021466453.2 → XP_021322128.1  kinase suppressor of Ras 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9P7D5
      Related
      ENSDARP00000128838.1, ENSDART00000157145.3
      Conserved Domains (3) summary
      cd00029
      Location:402 → 444
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd14152
      Location:637 → 915
      STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
      pfam13543
      Location:44 → 171
      KSR1-SAM; SAM like domain present in kinase suppressor RAS 1

    2. XM_021466452.2 → XP_021322127.1  kinase suppressor of Ras 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9NYP7
      Conserved Domains (3) summary
      cd00029
      Location:402 → 444
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd14152
      Location:651 → 929
      STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
      pfam13543
      Location:44 → 171
      KSR1-SAM; SAM like domain present in kinase suppressor RAS 1

    3. XM_021466455.2 → XP_021322130.1  kinase suppressor of Ras 1 isoform X6

      UniProtKB/TrEMBL
      A0A8M9PLR2
      Conserved Domains (3) summary
      cd00029
      Location:262 → 304
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd14152
      Location:511 → 789
      STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
      pfam13543
      Location:1 → 31
      KSR1-SAM; SAM like domain present in kinase suppressor RAS 1

    4. XM_021466454.2 → XP_021322129.1  kinase suppressor of Ras 1 isoform X5

      UniProtKB/TrEMBL
      A0A8M9PCG5
      Related
      ENSDARP00000128013.1, ENSDART00000154254.3
      Conserved Domains (3) summary
      cd00029
      Location:276 → 318
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd14152
      Location:525 → 803
      STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
      pfam13543
      Location:4 → 45
      KSR1-SAM; SAM like domain present in kinase suppressor RAS 1

    5. XM_068213759.1 → XP_068069860.1  kinase suppressor of Ras 1 isoform X4

      Related
      ENSDARP00000048102.6, ENSDART00000048103.7

    6. XM_068213758.1 → XP_068069859.1  kinase suppressor of Ras 1 isoform X3

      Related
      ENSDARP00000129721.1, ENSDART00000155473.2
    Nucleotide Protein Strain
    Heading Accession and Version

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