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    a2ml2 alpha-2-macroglobulin-like 2 [ Danio rerio (zebrafish) ]

    Gene ID: 100006993, updated on 9-Dec-2024

    Summary

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    Official Symbol
    a2ml2provided by ZNC
    Official Full Name
    alpha-2-macroglobulin-like 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1342
    See related
    Ensembl:ENSDARG00000095315 AllianceGenome:ZFIN:ZDB-GENE-030131-1342
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb68b01; wu:fb68b01; si:dkey-52d15.2
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in nervous system development. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be located in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See a2ml2 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (21079707..21109625, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (21143947..21173875, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene alpha-2-macroglobulin-like protein 1 Neighboring gene si:ch211-212c13.10 Neighboring gene alpha-2-macroglobulin-like Neighboring gene alpha-2-macroglobulin-like 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Dynamic evolutionary pattern of alpha2-macroglobulin in a model organism, the zebrafish (Danio rerio). Padhi A, et al. Mol Immunol, 2008 Jun. PMID 18485482
    2. Transcriptomic characterization of adult zebrafish infected with Streptococcus agalactiae. Wu XM, et al. Fish Shellfish Immunol, 2019 Nov. PMID 31533079
    3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-2-macroglobulin-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001423273.1 → NP_001410202.1  alpha-2-macroglobulin-like 2

      Status: VALIDATED

      Source sequence(s)
      CR626907
      UniProtKB/TrEMBL
      A0A8M9PM16
      Related
      ENSDART00000142311.3

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      21079707..21109625 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068213435.1 → XP_068069536.1  alpha-2-macroglobulin-like 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PM16

    RNA

    1. XR_011006317.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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