U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    dhx37 DEAH (Asp-Glu-Ala-His) box polypeptide 37 [ Danio rerio (zebrafish) ]

    Gene ID: 100009635, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    dhx37provided by ZNC
    Official Full Name
    DEAH (Asp-Glu-Ala-His) box polypeptide 37provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-4505
    See related
    Ensembl:ENSDARG00000062612 AllianceGenome:ZFIN:ZDB-GENE-030131-4505
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fd11d06; im:7151586; wu:fd11d06; zgc:158802
    Summary
    Predicted to enable RNA binding activity and helicase activity. Acts upstream of or within positive regulation of mRNA splicing, via spliceosome. Predicted to be active in nucleolus. Human ortholog(s) of this gene implicated in 46,XY sex reversal. Orthologous to human DHX37 (DEAH-box helicase 37). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See dhx37 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (4516831..4574329, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (4460125..4517660, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene si:ch211-166a6.5 Neighboring gene SRR1 domain containing Neighboring gene glycoprotein Ib platelet subunit beta Neighboring gene septin 5a

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Defective escape behavior in DEAH-box RNA helicase mutants improved by restoring glycine receptor expression. Hirata H, et al. J Neurosci, 2013 Sep 11. PMID 24027265, Free PMC Article
    2. A Multifunctional Mutagenesis System for Analysis of Gene Function in Zebrafish. Quach HN, et al. G3 (Bethesda), 2015 Apr 2. PMID 25840430, Free PMC Article
    3. Evolution and Expression of Paxillin Genes in Teleost Fish. Jacob AE, et al. PLoS One, 2016. PMID 27806088, Free PMC Article
    4. In vivo proteomic mapping through GFP-directed proximity-dependent biotin labelling in zebrafish. Xiong Z, et al. Elife, 2021 Feb 16. PMID 33591275, Free PMC Article
    5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of mRNA splicing, via spliceosome IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    probable ATP-dependent RNA helicase DHX37
    NP_001076473.2
    XP_005172500.1
    XP_005172501.1
    XP_068078944.1
    XP_068078945.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083004.2 → NP_001076473.2  probable ATP-dependent RNA helicase DHX37

      Status: PROVISIONAL

      Source sequence(s)
      CU469504
      UniProtKB/TrEMBL
      A0A8M1NCA9, A0A8M9Q9G2, B8JLP0, F6NQ66
      Related
      ENSDARP00000085164.5, ENSDART00000090731.6
      Conserved Domains (1) summary
      COG1643
      Location:198 → 1006
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      4516831..4574329 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005172444.5 → XP_005172501.1  probable ATP-dependent RNA helicase DHX37 isoform X3

      See identical proteins and their annotated locations for XP_005172501.1

      UniProtKB/TrEMBL
      A0A8M2BJM4, A0A8M9Q9G2
      Conserved Domains (6) summary
      smart00490
      Location:583 → 667
      HELICc; helicase superfamily c-terminal domain
      smart00847
      Location:761 → 813
      HA2; Helicase associated domain (HA2) Add an annotation
      COG1643
      Location:200 → 1007
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd00046
      Location:272 → 412
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam04408
      Location:730 → 781
      HA2; Helicase associated domain (HA2)
      pfam07717
      Location:918 → 1004
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    2. XM_005172443.5 → XP_005172500.1  probable ATP-dependent RNA helicase DHX37 isoform X3

      See identical proteins and their annotated locations for XP_005172500.1

      UniProtKB/TrEMBL
      A0A8M2BJM4, A0A8M9Q9G2
      Conserved Domains (6) summary
      smart00490
      Location:583 → 667
      HELICc; helicase superfamily c-terminal domain
      smart00847
      Location:761 → 813
      HA2; Helicase associated domain (HA2) Add an annotation
      COG1643
      Location:200 → 1007
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd00046
      Location:272 → 412
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam04408
      Location:730 → 781
      HA2; Helicase associated domain (HA2)
      pfam07717
      Location:918 → 1004
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    3. XM_068222844.1 → XP_068078945.1  probable ATP-dependent RNA helicase DHX37 isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q9G2

    4. XM_068222843.1 → XP_068078944.1  probable ATP-dependent RNA helicase DHX37 isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q9G2
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools