fbxl14b F-box and leucine-rich repeat protein 14b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fbxl14bprovided by ZNC
Official Full Name: F-box and leucine-rich repeat protein 14bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-3556
See related: Ensembl:ENSDARG00000045801 AllianceGenome:ZFIN:ZDB-GENE-030131-3556
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ppab; fbxl14; wu:fc44g06
Summary: Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within protein ubiquitination. Part of SCF ubiquitin ligase complex. Is expressed in hindbrain and midbrain. Orthologous to human FBXL14 (F-box and leucine rich repeat protein 14). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 4

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (8610170..8611634, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (8609254..8610718, complement)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Concludes that patterning of ppa mRNA could reflect a constraint on ppa function that is not common among F-box genes.
Title: A conserved F-box gene with unusual transcript localization.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ubiquitin-protein transferase activity	IC Inferred by Curator more info	PubMed

Process	Evidence Code	Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein ubiquitination	IC Inferred by Curator more info	PubMed

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SCF ubiquitin ligase complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: F-box/LRR-repeat protein 14b

Names: partner of paired b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001015043.2 → NP_001015043.1 F-box/LRR-repeat protein 14b

See identical proteins and their annotated locations for NP_001015043.1

Status: PROVISIONAL

Source sequence(s)

BC163002

UniProtKB/TrEMBL

B3DI53, Q5RH13

Related

ENSDARP00000067321.3, ENSDART00000067322.5

Conserved Domains (3) summary

cd09293
Location:90 → 296

AMN1; Antagonist of mitotic exit network protein 1

sd00034
Location:92 → 118

LRR_AMN1; leucine-rich repeat [structural motif]

pfam12937
Location:5 → 46

F-box-like