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    oxr1b oxidation resistance 1b [ Danio rerio (zebrafish) ]

    Gene ID: 570476, updated on 9-Dec-2024

    Summary

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    Official Symbol
    oxr1bprovided by ZNC
    Official Full Name
    oxidation resistance 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2438
    See related
    Ensembl:ENSDARG00000063310 AllianceGenome:ZFIN:ZDB-GENE-030131-2438
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc07g10; wu:fc07g10; si:dkeyp-84f11.5
    Summary
    Acts upstream of or within cranial ganglion development; regulation of apoptotic process; and regulation of response to oxidative stress. Predicted to be active in nucleus. Is expressed in several structures, including blastomere; liver; nervous system; pleuroperitoneal region; and prechordal plate. Human ortholog(s) of this gene implicated in cerebellar hyplasia/atrophy, epilepsy, and global developmental delay. Orthologous to human OXR1 (oxidation resistance 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See oxr1b in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (7309050..7406911, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (7390125..7487982, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 127b Neighboring gene squalene epoxidase b Neighboring gene NAD(P)HX epimerase Neighboring gene RAB25, member RAS oncogene family a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A novel recessive mutation in OXR1 is identified in patient with hearing loss recapitulated by the knockdown zebrafish. Li Y, et al. Hum Mol Genet, 2023 Feb 19. PMID 36130215, Free PMC Article
    2. The embryonic expression patterns of zebrafish genes encoding LysM-domains. Laroche FJ, et al. Gene Expr Patterns, 2013 Oct. PMID 23567754
    3. Oxr1a prevents the premature ovarian failure by regulating oxidative stress and mitochondrial function in zebrafish. Xu H, et al. Free Radic Biol Med, 2023 Jul. PMID 37031846
    4. Expression profiling and functional characterization of the duplicated Oxr1b gene in zebrafish. Xu H, et al. Comp Biochem Physiol Part D Genomics Proteomics, 2021 Sep. PMID 34111665
    5. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within cranial ganglion development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    oxidation resistance protein 1b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045203.1 → NP_001038668.1  oxidation resistance protein 1b

      See identical proteins and their annotated locations for NP_001038668.1

      Status: PROVISIONAL

      Source sequence(s)
      BX890617
      UniProtKB/TrEMBL
      A0A8N7XJA0, F1Q4W8, Q1LVA3
      Related
      ENSDARP00000086811.5, ENSDART00000092379.6
      Conserved Domains (3) summary
      smart00584
      Location:585 → 749
      TLDc; domain in TBC and LysM domain containing proteins
      COG1388
      Location:3 → 45
      LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
      pfam01476
      Location:3 → 45
      LysM; LysM domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      7309050..7406911 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005159459.4 → XP_005159516.1  oxidation resistance protein 1b isoform X2

      UniProtKB/TrEMBL
      A0A8M2B610
      Conserved Domains (3) summary
      smart00584
      Location:654 → 814
      TLDc; domain in TBC and LysM domain containing proteins
      COG1388
      Location:73 → 141
      LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
      pfam01476
      Location:99 → 141
      LysM; LysM domain

    2. XM_005159458.4 → XP_005159515.1  oxidation resistance protein 1b isoform X1

      UniProtKB/TrEMBL
      A0A8M2B612, I3ISS4
      Related
      ENSDARP00000125967.1, ENSDART00000151137.3
      Conserved Domains (3) summary
      smart00584
      Location:681 → 841
      TLDc; domain in TBC and LysM domain containing proteins
      COG1388
      Location:73 → 141
      LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
      pfam01476
      Location:99 → 141
      LysM; LysM domain

    3. XM_009294057.4 → XP_009292332.1  oxidation resistance protein 1b isoform X3

      UniProtKB/TrEMBL
      A0A8M3AK20
      Related
      ENSDARP00000086807.5, ENSDART00000092375.6
      Conserved Domains (1) summary
      smart00584
      Location:80 → 240
      TLDc; domain in TBC and LysM domain containing proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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