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    srl sarcalumenin [ Danio rerio (zebrafish) ]

    Gene ID: 449670, updated on 4-Jan-2025

    Summary

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    Official Symbol
    srlprovided by ZNC
    Official Full Name
    sarcalumeninprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-061110-91
    See related
    Ensembl:ENSDARG00000104587 AllianceGenome:ZFIN:ZDB-GENE-061110-91
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:6899248; wu:fb94b10; zgc:153844
    Summary
    Predicted to enable GTP binding activity. Predicted to be involved in endocytosis and endosomal transport. Predicted to be located in membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in adaxial cell; cardiovascular system; musculature system; and somite. Orthologous to human SRL (sarcalumenin). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See srl in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (12131701..12186921, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (55900839..55956069, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 100 Neighboring gene adenylate cyclase type 9 pseudogene Neighboring gene transcription factor AP-4 (activating enhancer binding protein 4) Neighboring gene GLIS family zinc finger 2b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Pbx and Prdm1a transcription factors differentially regulate subsets of the fast skeletal muscle program in zebrafish. Yao Z, et al. Biol Open, 2013 Jun 15. PMID 23789105, Free PMC Article
    2. Pbx homeodomain proteins direct Myod activity to promote fast-muscle differentiation. Maves L, et al. Development, 2007 Sep. PMID 17699609
    3. CTCF promotes muscle differentiation by modulating the activity of myogenic regulatory factors. Delgado-Olguín P, et al. J Biol Chem, 2011 Apr 8. PMID 21288905, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sarcalumenin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077531.1 → NP_001070999.1  sarcalumenin precursor

      See identical proteins and their annotated locations for NP_001070999.1

      Status: PROVISIONAL

      Source sequence(s)
      BC124749
      UniProtKB/TrEMBL
      A0A8M1NBQ9, A0AUR2
      Related
      ENSDARP00000153671.1, ENSDART00000189553.1
      Conserved Domains (2) summary
      cd09913
      Location:104 → 345
      EHD; Eps15 homology domain (EHD), C-terminal domain
      pfam16880
      Location:56 → 83
      EHD_N; N-terminal EH-domain containing protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      12131701..12186921 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009299804.4 → XP_009298079.1  sarcalumenin isoform X1

      UniProtKB/TrEMBL
      A0A0R4IRI3, A0A8M3B8K9
      Related
      ENSDARP00000138572.1, ENSDART00000165131.3
      Conserved Domains (2) summary
      cd09913
      Location:92 → 333
      EHD; Eps15 homology domain (EHD), C-terminal domain
      pfam16880
      Location:56 → 87
      EHD_N; N-terminal EH-domain containing protein
    Nucleotide Protein Strain
    Heading Accession and Version

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