pdxka pyridoxal (pyridoxine, vitamin B6) kinase a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pdxkaprovided by ZNC
Official Full Name: pyridoxal (pyridoxine, vitamin B6) kinase aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-8376
See related: Ensembl:ENSDARG00000088959 AllianceGenome:ZFIN:ZDB-GENE-030131-8376
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: pdxkl; cb1056; fb10c12; wu:fa55a03; wu:fb10c12; zgc:101900; si:dkey-281i8.2
Summary: Predicted to enable pyridoxal kinase activity. Predicted to be involved in pyridoxal 5'-phosphate salvage. Predicted to act upstream of or within phosphorylation. Predicted to be active in cytosol. Is expressed in pronephros and ventricular zone. Orthologous to human PDXK (pyridoxal kinase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 9

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (19623406..19657400)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (19809130..19842589)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb10c12.x1 (e-PCR)
- UniSTS:202808

z99205 (e-PCR), detects polymorphism
- UniSTS:238941

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pyridoxal 5'-phosphate salvage	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pyridoxal (pyridoxine, vitamin B6) kinase a

Names: pyridoxal (pyridoxine, vitamin B6) kinase, like

NP_001119921.1

EC 2.7.1.35

XP_021334450.1

EC 2.7.1.35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001126449.1 → NP_001119921.1 pyridoxal (pyridoxine, vitamin B6) kinase a

See identical proteins and their annotated locations for NP_001119921.1

Status: PROVISIONAL

Source sequence(s)

BX677668

UniProtKB/TrEMBL

A0A8M1NHG6, B0S7H1

Related

ENSDARP00000113113.1, ENSDART00000147662.3

Conserved Domains (1) summary

cl00192
Location:4 → 305

ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007120.7 Reference GRCz11 Primary Assembly

Range

19623406..19657400

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021478775.2 → XP_021334450.1 pyridoxal (pyridoxine, vitamin B6) kinase a isoform X1

UniProtKB/TrEMBL

A0A8M9QJU9

Conserved Domains (1) summary

cl00192
Location:4 → 306

ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...