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    ssrp1a structure specific recognition protein 1a [ Danio rerio (zebrafish) ]

    Gene ID: 386844, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ssrp1aprovided by ZNC
    Official Full Name
    structure specific recognition protein 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-031118-9
    See related
    Ensembl:ENSDARG00000037397 AllianceGenome:ZFIN:ZDB-GENE-031118-9
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ssrp1; wu:fa11b03; wu:fd10f06
    Summary
    Predicted to enable histone binding activity and nucleosome binding activity. Acts upstream of or within regulation of cell cycle. Predicted to be located in chromosome and nucleolus. Predicted to be part of FACT complex. Is expressed in several structures, including dorsal telencephalon; eye; hematopoietic multipotent progenitor cell; liver; and ventral wall of dorsal aorta. Orthologous to human SSRP1 (structure specific recognition protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ssrp1a in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (21980446..22015326, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (21683201..21718081, complement)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 3a Neighboring gene uncharacterized LOC137487583 Neighboring gene cardiotrophin-like cytokine factor 1 Neighboring gene solute carrier family 43 member 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Mutations linked to loss of cell cycle control can render cells responsive to local differentiation cues. Cerveny KL, et al. MicroPubl Biol, 2021. PMID 34723143, Free PMC Article
    2. Ssrp1a controls organogenesis by promoting cell cycle progression and RNA synthesis. Koltowska K, et al. Development, 2013 May. PMID 23515471, Free PMC Article
    3. Haematopoietic stem cell-dependent Notch transcription is mediated by p53 through the Histone chaperone Supt16h. Espanola SG, et al. Nat Cell Biol, 2020 Dec. PMID 33230303, Free PMC Article
    4. TIF1gamma controls erythroid cell fate by regulating transcription elongation. Bai X, et al. Cell, 2010 Jul 9. PMID 20603019, Free PMC Article
    5. Proteome dynamics in neutrophils of adult zebrafish upon chemically-induced inflammation. Singh SK, et al. Fish Shellfish Immunol, 2014 Sep. PMID 25014315

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ssrp1a is essential for proliferation and differentiation during eye and liver organogenesis.
      Title: Ssrp1a controls organogenesis by promoting cell cycle progression and RNA synthesis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of chromatin organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of FACT complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    FACT complex subunit SSRP1a
    Names
    structure specific recognition protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212802.2 → NP_997967.2  FACT complex subunit SSRP1a

      Status: VALIDATED

      Source sequence(s)
      AA494805, BX510356, CT594375, CT607671
      UniProtKB/TrEMBL
      A0A8M1PHY6, F1QEB4
      Related
      ENSDARP00000114529.1, ENSDART00000137795.3
      Conserved Domains (4) summary
      COG5165
      Location:21 → 512
      POB3; Nucleosome-binding factor SPN, POB3 subunit [Transcription / DNA replication, recombination, and repair / Chromatin structure and dynamics]
      cd13231
      Location:333 → 428
      PH2_SSRP1-like; Structure Specific Recognition protein 1 (SSRP1) Pleckstrin homology (PH) domain, repeat 2
      pfam00505
      Location:546 → 613
      HMG_box; HMG (high mobility group) box
      pfam03531
      Location:75 → 285
      SSrecog; Structure-specific recognition protein (SSRP1)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      21980446..22015326 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394904.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      174031..200429 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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