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    zgc:153115 zgc:153115 [ Danio rerio (zebrafish) ]

    Gene ID: 768186, updated on 19-Jan-2025

    Summary

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    Official Symbol
    zgc:153115provided by ZNC
    Official Full Name
    zgc:153115provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-061013-418
    See related
    Ensembl:ENSDARG00000069342 AllianceGenome:ZFIN:ZDB-GENE-061013-418
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    klf14; klf16; wu:fc41a09; wu:fi22b08; zgc:152867
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within endocrine pancreas development. [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See zgc:153115 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (7238549..7246857, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (7366943..7375251, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene si:ch211-13f8.1 Neighboring gene collagen beta(1-O)galactosyltransferase 2a Neighboring gene si:dkeyp-106c3.1 Neighboring gene si:dkeyp-106c3.2 Neighboring gene agouti signaling protein, nonagouti homolog (mouse) 2b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Bioinformatic Analysis of Roquin Family Reveals Their Potential Role in Immune System. Li X, et al. Int J Mol Sci, 2024 May 28. PMID 38892048, Free PMC Article
    2. Single-cell analyses identify distinct and intermediate states of zebrafish pancreatic islet development. Lu CJ, et al. J Mol Cell Biol, 2019 Jun 1. PMID 30407522, Free PMC Article
    3. Genome-wide analysis of the zebrafish Klf family identifies two genes important for erythroid maturation. Xue Y, et al. Dev Biol, 2015 Jul 15. PMID 26015096
    4. Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of β-Cell Mass Deficits. O'Hare EA, et al. Mol Endocrinol, 2016 Apr. PMID 26963759, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC152867

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within endocrine pancreas development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein LOC768186

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077329.2 → NP_001070797.2  uncharacterized protein LOC768186

      See identical proteins and their annotated locations for NP_001070797.2

      Status: VALIDATED

      Source sequence(s)
      BX000469
      UniProtKB/TrEMBL
      A0A8M1NBK3, A8E7A9
      Related
      ENSDARP00000119414.1, ENSDART00000146434.3
      Conserved Domains (4) summary
      COG5048
      Location:153 → 201
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:144 → 163
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:199 → 221
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:185 → 208
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      7238549..7246857 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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